General Information:

Id: 3,792 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Srikanth V et al.(2011) Advanced glycation endproducts and their receptor RAGE in Alzheimers disease Neurobiol. Aging 32: 763-777 [PMID: 19464758]

Interaction Information:

Comment AGEs and TNF-alpha were shown to activate the RAGE gene through the transcription factors NF-kappaB and Sp-1, causing enhanced AGE-RAGE interactions, which would lead to an exacerbation of AGE-RAGE mediated damage.
Formal Description
Interaction-ID: 37734

drug/chemical compound

Advanced glycation end-product

increases_activity of

gene/protein

AGER

through the transcription factors NF-kappaB and Sp-1, causing enhanced AGE-RAGE interactions