General Information:

Id: 3,792 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Srikanth V et al.(2011) Advanced glycation endproducts and their receptor RAGE in Alzheimers disease Neurobiol. Aging 32: 763-777 [PMID: 19464758]

Interaction Information:

Comment All AGEs tested, regardless of their degree of modification, were found to induce ROS formation in both microglial (CHME-5) and astroglial cells (U373MG), while only highly modified AGEs were able to decrease the cell viability and induce apoptosis.
Formal Description
Interaction-ID: 37646

drug/chemical compound

Advanced glycation end-product

increases_quantity of

drug/chemical compound

Reactive oxygen species

in both microglial (CHME-5) and astroglial cells (U373MG)