General Information:

Id: 3,792 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Srikanth V et al.(2011) Advanced glycation endproducts and their receptor RAGE in Alzheimers disease Neurobiol. Aging 32: 763-777 [PMID: 19464758]

Interaction Information:

Comment Nearly all of those neurons which show diffuse cytosolic AGE immunoreactivity also contain hyperphosphorylated Tau, suggesting a link between AGE accumulation and the formation of early neurofibrillary tangles.
Formal Description
Interaction-ID: 37482

drug/chemical compound

Advanced glycation end-product

cooccurs with

protein modification

MAPT-hyperphos

suggesting a link between AGE accumulation and the formation of early neurofibrillary tangles