General Information:

Id: 3,790
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
BBTO:0000793 SH-SY5Y cell
article
Reference: Yin F et al.(2011) Silibinin: a novel inhibitor of Abeta aggregation Neurochem. Int. 58: 399-403 [PMID: 21185897]

Interaction Information:

Comment Silibinin appears to act as a novel inhibitor of Abeta aggregation and this effect showed dose-dependency.
Formal Description
Interaction-ID: 37425

drug/chemical compound

Silibinin

decreases_quantity of

Comment Silibinin prevented SH-SY5Y cells from injuries caused by Abeta (1-42)-induced oxidative stress by decreasing H2O2 production in Abeta (1-42)-stressed neurons.
Formal Description
Interaction-ID: 37427

drug/chemical compound

Silibinin

affects_activity of

caused by Abeta (42)
Comment Silibinin prevented SH-SY5Y cells from injuries caused by Abeta (1-42)-induced oxidative stress by decreasing H2O2 production in Abeta (1-42)-stressed neurons.
Formal Description
Interaction-ID: 37428

drug/chemical compound

Silibinin

decreases_activity of

Comment Silibinin prevented SH-SY5Y cells from injuries caused by Abeta (1-42)-induced oxidative stress by decreasing H2O2 production in Abeta (1-42)-stressed neurons.
Formal Description
Interaction-ID: 37429

drug/chemical compound

Silibinin

decreases_quantity of

drug/chemical compound

H2O2

in Abeta (1-42)-stressed neurons