General Information:

Id: 379
Diseases: Amyotrophic lateral sclerosis
Mus musculus
SOD1(G93A) transgenic mouse
BTO:0001279 spinal cord
article
Reference: Petri S et al.(2007) The lipophilic metal chelators DP-109 and DP-460 are neuroprotective in a transgenic mouse model of amyotrophic lateral sclerosis J. Neurochem. 102: 991-1000 [PMID: 17630988]

Interaction Information:

Comment Treatment of SOD1(G93A) transgenic mice with the lipophilic metal chelators DP-109 and DP-460 (calcium, zinc, and copper chelating compounds) resulted in a significant delay of the onset of ALS symptoms. DP-109 and DP-460 are diester derivatives of BAPTA [1,2-bis(2-aminophenyloxy)ethane-N,N,N',N'-tetra acetic acid].
Formal Description
Interaction-ID: 1545

drug/chemical compound

Lipophilic metal chelator DP-109

decreases_activity of

disease

Amyotrophic lateral sclerosis

in SOD1(G93A) transgenic mice
Comment Treatment of SOD1(G93A) transgenic mice with the lipophilic metal chelators DP-109 and DP-460 (calcium, zinc, and copper chelating compounds) resulted in a significant reduction of motor neuron loss. DP-109 and DP-460 are diester derivatives of BAPTA [1,2-bis(2-aminophenyloxy)ethane-N,N,N',N'-tetra acetic acid].
Formal Description
Interaction-ID: 1546

drug/chemical compound

Lipophilic metal chelator DP-109

decreases_activity of

in SOD1(G93A) transgenic mice
Comment Treatment of SOD1(G93A) transgenic mice with the lipophilic metal chelators DP-109 and DP-460 (calcium, zinc, and copper chelating compounds) resulted in a significant delay of the onset of ALS symptoms. DP-109 and DP-460 are diester derivatives of BAPTA [1,2-bis(2-aminophenyloxy)ethane-N,N,N',N'-tetra acetic acid].
Formal Description
Interaction-ID: 1547

drug/chemical compound

Lipophilic metal chelator DP-460

decreases_activity of

disease

Amyotrophic lateral sclerosis

in SOD1(G93A) transgenic mice
Comment Treatment of SOD1(G93A) transgenic mice with the lipophilic metal chelators DP-109 and DP-460 (calcium, zinc, and copper chelating compounds) resulted in a significant reduction of motor neuron loss. DP-109 and DP-460 are diester derivatives of BAPTA [1,2-bis(2-aminophenyloxy)ethane-N,N,N',N'-tetra acetic acid].
Formal Description
Interaction-ID: 1548

drug/chemical compound

Lipophilic metal chelator DP-460

decreases_activity of

in SOD1(G93A) transgenic mice
Comment Treatment of SOD1(G93A) transgenic mice with the lipophilic metal chelators DP-109 and DP-460 (calcium, zinc, and copper chelating compounds) resulted in decreased astrocytosis. DP-109 and DP-460 are diester derivatives of BAPTA [1,2-bis(2-aminophenyloxy)ethane-N,N,N',N'-tetra acetic acid].
Formal Description
Interaction-ID: 1549

drug/chemical compound

Lipophilic metal chelator DP-109

decreases_activity of

in SOD1(G93A) transgenic mice
Comment Treatment of SOD1(G93A) transgenic mice with the lipophilic metal chelators DP-109 and DP-460 (calcium, zinc, and copper chelating compounds) resulted in decreased astrocytosis. DP-109 and DP-460 are diester derivatives of BAPTA [1,2-bis(2-aminophenyloxy)ethane-N,N,N',N'-tetra acetic acid].
Formal Description
Interaction-ID: 1550

drug/chemical compound

Lipophilic metal chelator DP-460

decreases_activity of

in SOD1(G93A) transgenic mice
Comment Treatment of SOD1(G93A) transgenic mice with the lipophilic metal chelator DP-109, but not with DP-460, resulted in decreased microgliosis. DP-109 and DP-460 are diester derivatives of BAPTA [1,2-bis(2-aminophenyloxy)ethane-N,N,N',N'-tetra acetic acid].
Formal Description
Interaction-ID: 1551

drug/chemical compound

Lipophilic metal chelator DP-109

decreases_activity of

in SOD1(G93A) transgenic mice
Comment Treatment of SOD1(G93A) transgenic mice with the lipophilic metal chelators DP-109 and DP-460 (calcium, zinc, and copper chelating compounds) resulted in decreased oxidative stress. DP-109 and DP-460 are diester derivatives of BAPTA [1,2-bis(2-aminophenyloxy)ethane-N,N,N',N'-tetra acetic acid].
Formal Description
Interaction-ID: 1553

drug/chemical compound

Lipophilic metal chelator DP-109

decreases_activity of

in SOD1(G93A) transgenic mice
Comment Treatment of SOD1(G93A) transgenic mice with the lipophilic metal chelators DP-109 and DP-460 (calcium, zinc, and copper chelating compounds) resulted in decreased oxidative stress. DP-109 and DP-460 are diester derivatives of BAPTA [1,2-bis(2-aminophenyloxy)ethane-N,N,N',N'-tetra acetic acid].
Formal Description
Interaction-ID: 1554

drug/chemical compound

Lipophilic metal chelator DP-460

decreases_activity of

in SOD1(G93A) transgenic mice
Comment Protein expression of TNF-alpha was up-regulated as well in the ventral horn of vehicle-treated G93A but not in DP-109- and DP-460-treated G93A mice as compared with wild-type mice. The lipophilic metal chelators DP-109 and DP-460 are diester derivatives of BAPTA [1,2-bis(2-aminophenyloxy)ethane-N,N,N',N'-tetra acetic acid].
Formal Description
Interaction-ID: 1555

gene/protein mutant

SOD1-p.G93A

increases_quantity of

gene/protein

TNF

in SOD1(G93A) transgenic mice
Drugbank entries Show/Hide entries for TNF
Comment Protein expression of TNF-alpha was up-regulated as well in the ventral horn of vehicle-treated G93A but not in DP-109- and DP-460-treated G93A mice as compared with wild-type mice. The lipophilic metal chelators DP-109 and DP-460 are diester derivatives of BAPTA [1,2-bis(2-aminophenyloxy)ethane-N,N,N',N'-tetra acetic acid].
Formal Description
Interaction-ID: 1557

drug/chemical compound

Lipophilic metal chelator DP-460

NOT increases_quantity of

gene/protein

TNF

in SOD1(G93A) transgenic mice
Drugbank entries Show/Hide entries for TNF
Comment Protein expression of TNF-alpha was up-regulated as well in the ventral horn of vehicle-treated G93A but not in DP-109- and DP-460-treated G93A mice as compared with wild-type mice. The lipophilic metal chelators DP-109 and DP-460 are diester derivatives of BAPTA [1,2-bis(2-aminophenyloxy)ethane-N,N,N',N'-tetra acetic acid].
Formal Description
Interaction-ID: 1558

drug/chemical compound

Lipophilic metal chelator DP-109

NOT increases_quantity of

gene/protein

TNF

in SOD1(G93A) transgenic mice
Drugbank entries Show/Hide entries for TNF
Comment Protein expression of HIF-1alpha was shown to be significantly up-regulated by the treatment with DP-109 (fourfold), and, more prominently, with DP-460 (eightfold) in the spinal cord of G93A mice at 110 days of age. The lipophilic metal chelators DP-109 and DP-460 are diester derivatives of BAPTA [1,2-bis(2-aminophenyloxy)ethane-N,N,N',N'-tetra acetic acid].
Formal Description
Interaction-ID: 1559

drug/chemical compound

Lipophilic metal chelator DP-109

increases_quantity of

gene/protein

HIF1A

in SOD1(G93A) transgenic mice
Drugbank entries Show/Hide entries for HIF1A
Comment Protein expression of HIF-1alpha was shown to be significantly up-regulated by the treatment with DP-109 (fourfold), and, more prominently, with DP-460 (eightfold) in the spinal cord of G93A mice at 110 days of age. The lipophilic metal chelators DP-109 and DP-460 are diester derivatives of BAPTA [1,2-bis(2-aminophenyloxy)ethane-N,N,N',N'-tetra acetic acid].
Formal Description
Interaction-ID: 1561

drug/chemical compound

Lipophilic metal chelator DP-460

increases_quantity of

gene/protein

HIF1A

in SOD1(G93A) transgenic mice
Drugbank entries Show/Hide entries for HIF1A
Comment The spinal mRNA expression of VEGF as a target gene of HIF- 1alpha was shown to be induced by both chelators DP-109 and DP-460; the increase was significant only in the DP-460-treated G93A mice. The lipophilic metal chelators DP-109 and DP-460 are diester derivatives of BAPTA [1,2-bis(2-aminophenyloxy)ethane-N,N,N',N'-tetra acetic acid].
Formal Description
Interaction-ID: 1562

drug/chemical compound

Lipophilic metal chelator DP-460

increases_expression of

gene/protein

VEGFA

in SOD1(G93A) transgenic mice
Drugbank entries Show/Hide entries for VEGFA