General Information:

Id: 378 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Obesity - [OMIM]
Mus musculus
GPAT1-/- mouse
Reference: Yazdi M et al.(2008) The role of mitochondrial glycerol-3-phosphate acyltransferase-1 in regulating lipid and glucose homeostasis in high-fat diet fed mice Biochem. Biophys. Res. Commun. 369: 1065-1070 [PMID: 18339309]

Interaction Information:

Comment Female GPAT1-/- mice had reduced body weight-gain and adiposity when fed chow diet compared with littermate wild-type controls, they showed decreased liver TAG content, plasma cholesterol and TAG levels and increased ex vivo liver fatty acid oxidation and plasma ketone bodies. However when fed a long-term high-fat diet these beneficial effects were abolished and the glucose tolerance tended to be impaired in female GPAT1-/- mice. There were no changes in male GPAT1-/- mice fed either chow of high-fat diet except for increased plasma ketone bodies on chow diet, indicating a gender-specific phenotype.
Formal Description
Interaction-ID: 12651



affects_activity of

in liver; in female mice fed chow diet