CIDeRGeneral Information:
| Id: | 378 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Fatty liver disease, nonalcoholic Insulin resistance Obesity - [OMIM] |
| Mus musculus | |
| GPAT1-/- mouse | |
| article | |
| Reference: | Yazdi M et al.(2008) The role of mitochondrial glycerol-3-phosphate acyltransferase-1 in regulating lipid and glucose homeostasis in high-fat diet fed mice Biochem. Biophys. Res. Commun. 369: 1065-1070 [PMID: 18339309] |
Interaction Information:
| Comment | Female GPAT1-/- mice had reduced body weight-gain and adiposity when fed chow diet compared with littermate wild-type controls, they showed decreased liver TAG content, plasma cholesterol and TAG levels and increased ex vivo liver fatty acid oxidation and plasma ketone bodies. However when fed a long-term high-fat diet these beneficial effects were abolished and the glucose tolerance tended to be impaired in female GPAT1-/- mice. There were no changes in male GPAT1-/- mice fed either chow of high-fat diet except for increased plasma ketone bodies on chow diet, indicating a gender-specific phenotype. |
|
Formal Description Interaction-ID: 12651 |
gene/protein affects_activity of process |