General Information:

Id: 3,784
Diseases: Alzheimer disease - [OMIM]
Mammalia
article
Reference: Murata N et al.(2010) Silymarin attenuated the amyloid beta plaque burden and improved behavioral abnormalities in an Alzheimers disease mouse model Biosci. Biotechnol. Biochem. 74: 2299-2306 [PMID: 21071836]

Interaction Information:

Comment A marked suppression of Abeta fibril formation and neurotoxicity in PC12 cells after silymarin (an extract of milk thistle) treatment in vitro was observed.
Formal Description
Interaction-ID: 37359

drug/chemical compound

Silibinin

decreases_quantity of

complex/PPI

Amyloid beta peptide (fibrillar)

in PC12 cells
Comment A marked suppression of Abeta fibril formation and neurotoxicity in PC12 cells after silymarin (an extract of milk thistle) treatment in vitro was observed.
Formal Description
Interaction-ID: 37360

drug/chemical compound

Silibinin

decreases_activity of

process

neuron death

in PC12 cells; caused by Abeta neurotoxicity.
Comment Some studies showed a significant reduction in brain Abeta deposition and improvement in behavioral abnormalities in APP transgenic mice that had been preventively treated with a powdered diet containing 0.1% silymarin for 6 months.
Formal Description
Interaction-ID: 37361

drug/chemical compound

Silibinin

decreases_quantity of

in brain; of APP transgenic mice
Comment Some studies showed a significant reduction in brain Abeta deposition and improvement in behavioral abnormalities in APP transgenic mice that had been preventively treated with a powdered diet containing 0.1% silymarin for 6 months.
Formal Description
Interaction-ID: 37362

drug/chemical compound

Silibinin

decreases_activity of

phenotype

abnormal behavior

in APP transgenic mice
Comment The silymarin-treated APP mice also showed less anxiety than the vehicle-treated APP mice.
Formal Description
Interaction-ID: 37422

drug/chemical compound

Silibinin

decreases_activity of

Comment A silymarin intake induces a decline in Abeta oligomer production. Silymarin/Silibinin/Silybin is a major component of milk thistle and considered as a medicinal herb.
Formal Description
Interaction-ID: 37423

drug/chemical compound

Silibinin

decreases_quantity of

complex/PPI

Amyloid beta peptide (oligomer)

Comment A marked suppression of Abeta fibril formation and neurotoxicity in PC12 cells after silymarin (an extract of milk thistle) treatment in vitro was observed.
Formal Description
Interaction-ID: 80181

drug/chemical compound

Silibinin

decreases_activity of

in PC12 cells