General Information:

Id: 377 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Mus musculus
SOD1(G93A) transgenic mouse
BTO:0001279 spinal cord
article
Reference: Tortarolo M et al.(2003) Persistent activation of p38 mitogen-activated protein kinase in a mouse model of familial amyotrophic lateral sclerosis correlates with disease progression Mol. Cell. Neurosci. 23: 180-192 [PMID: 12812752]

Interaction Information:

Comment Accumulation of p38MAPK was found by immunoblotting in the spinal cord of G93A mice during the progression of disease, but no changes were detected in its mRNA levels.
Formal Description
Interaction-ID: 1534

gene/protein mutant

SOD1-p.G93A

increases_quantity of

gene/protein

p38 MAPK

in spinal cord
Comment In SOD1G93A mice with advanced disease (19 weeks), p38MAPK-P fluorescence was increased in the whole gray matter of the spinal cord including the substantia gelatinosa.
Formal Description
Interaction-ID: 1536

gene/protein mutant

SOD1-p.G93A

increases_activity of

gene/protein

p38 MAPK

in spinal cord
Comment Accumulation of p38MAPK was found by immunoblotting in the spinal cord of G93A mice during the progression of disease, but no changes were detected in its mRNA levels.
Formal Description
Interaction-ID: 13499

gene/protein mutant

SOD1-p.G93A

NOT increases_expression of

gene/protein

p38 MAPK

in spinal cord