General Information:

Id: 3,778
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
male
BTO:0001103 skeletal muscle, BTO:0001563 vastus lateralis
article
Reference: Sparks LM et al.(2005) A high-fat diet coordinately downregulates genes required for mitochondrial oxidative phosphorylation in skeletal muscle Diabetes 54: 1926-1933 [PMID: 15983191]

Interaction Information:

Comment High-fat diet (HFD) decreases the expression of six genes involved in oxidative phosphorylation (OXPHOS). Four were members of mitochondrial complex I: NDUFB3, NDUFB5, NDUFS1, and NDUFV1; one was SDHB in complex II and a mitochondrial carrier protein SLC25A12.
Formal Description
Interaction-ID: 36970

environment

high-fat diet

decreases_expression of

gene/protein

NDUFB3

in skeletal muscle
Drugbank entries Show/Hide entries for NDUFB3
Comment High-fat diet (HFD) decreases the expression of six genes involved in oxidative phosphorylation (OXPHOS). Four were members of mitochondrial complex I: NDUFB3, NDUFB5, NDUFS1, and NDUFV1; one was SDHB in complex II and a mitochondrial carrier protein SLC25A12.
Formal Description
Interaction-ID: 36972

environment

high-fat diet

decreases_expression of

gene/protein

NDUFB5

in skeletal muscle
Drugbank entries Show/Hide entries for NDUFB5
Comment High-fat diet (HFD) decreases the expression of six genes involved in oxidative phosphorylation (OXPHOS). Four were members of mitochondrial complex I: NDUFB3, NDUFB5, NDUFS1, and NDUFV1; one was SDHB in complex II and a mitochondrial carrier protein SLC25A12.
Formal Description
Interaction-ID: 36973

environment

high-fat diet

decreases_expression of

gene/protein

SDHB

in skeletal muscle
Drugbank entries Show/Hide entries for SDHB
Comment High-fat diet (HFD) decreases the expression of six genes involved in oxidative phosphorylation (OXPHOS). Four were members of mitochondrial complex I: NDUFB3, NDUFB5, NDUFS1, and NDUFV1; one was SDHB in complex II and a mitochondrial carrier protein SLC25A12.
Formal Description
Interaction-ID: 36974

environment

high-fat diet

decreases_expression of

gene/protein

SLC25A12

in skeletal muscle
Drugbank entries Show/Hide entries for SLC25A12
Comment High-fat diet (HFD) decreases the expression of six genes involved in oxidative phosphorylation (OXPHOS). Four were members of mitochondrial complex I: NDUFB3, NDUFB5, NDUFS1, and NDUFV1; one was SDHB in complex II and a mitochondrial carrier protein SLC25A12.
Formal Description
Interaction-ID: 36975

environment

high-fat diet

decreases_expression of

gene/protein

NDUFV1

in skeletal muscle
Drugbank entries Show/Hide entries for NDUFV1
Comment High-fat diet (HFD) decreases the expression of six genes involved in oxidative phosphorylation (OXPHOS). Four were members of mitochondrial complex I: NDUFB3, NDUFB5, NDUFS1, and NDUFV1; one was SDHB in complex II and a mitochondrial carrier protein SLC25A12.
Formal Description
Interaction-ID: 36976

environment

high-fat diet

decreases_expression of

gene/protein

NDUFS1

in skeletal muscle
Drugbank entries Show/Hide entries for NDUFS1
Comment Because expression levels of genes involved in the function of mitochondria decreased, the expression of genes known to be involved in mitochondrial biogenesis was examined. Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC1) alpha and PGC1beta mRNA were decreased by -20% and -25%, respectively. Mitochondrial transcription factor A (TFAM), a key activator of mitochondrial transcription and its genome replication, was not significantly changed, nor was nuclear respiratory factor 1 (NRF1).
Formal Description
Interaction-ID: 36977

environment

high-fat diet

decreases_expression of

gene/protein

PPARGC1A

in skeletal muscle
Comment Because expression levels of genes involved in the function of mitochondria decreased, the expression of genes known to be involved in mitochondrial biogenesis was examined. Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC1) alpha and PGC1beta mRNA were decreased by -20% and -25%, respectively. Mitochondrial transcription factor A (TFAM), a key activator of mitochondrial transcription and its genome replication, was not significantly changed, nor was nuclear respiratory factor 1 (NRF1).
Formal Description
Interaction-ID: 36979

environment

high-fat diet

decreases_expression of

gene/protein

PPARGC1B

in skeletal muscle
Comment Because expression levels of genes involved in the function of mitochondria decreased, the expression of genes known to be involved in mitochondrial biogenesis was examined. Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC1) alpha and PGC1beta mRNA were decreased by -20% and -25%, respectively. Mitochondrial transcription factor A (TFAM), a key activator of mitochondrial transcription and its genome replication, was not significantly changed, nor was nuclear respiratory factor 1 (NRF1).
Formal Description
Interaction-ID: 36982

environment

high-fat diet

NOT affects_expression of

gene/protein

TFAM

in skeletal muscle
Comment Because expression levels of genes involved in the function of mitochondria decreased, the expression of genes known to be involved in mitochondrial biogenesis was examined. Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC1) alpha and PGC1beta mRNA were decreased by -20% and -25%, respectively. Mitochondrial transcription factor A (TFAM), a key activator of mitochondrial transcription and its genome replication, was not significantly changed, nor was nuclear respiratory factor 1 (NRF1).
Formal Description
Interaction-ID: 36984

environment

high-fat diet

NOT affects_expression of

gene/protein

NRF1

in skeletal muscle
Comment THe results suggest a mechanism whereby HFD downregulates genes necessary for OXPHOS and mitochondrial biogenesis. These changes mimic those observed in diabetes and insulin resistance and, if sustained, may result in mitochondrial dysfunction in the prediabetic / insulin-resistant state.
Formal Description
Interaction-ID: 37013

environment

high-fat diet

decreases_activity of

in skeletal muscle
Comment THe results suggest a mechanism whereby HFD downregulates genes necessary for OXPHOS and mitochondrial biogenesis. These changes mimic those observed in diabetes and insulin resistance and, if sustained, may result in mitochondrial dysfunction in the prediabetic / insulin-resistant state.
Formal Description
Interaction-ID: 37014

environment

high-fat diet

decreases_activity of

in skeletal muscle
Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of LOC51778 (NM_016599).
Formal Description
Interaction-ID: 37015

environment

high-fat diet

decreases_expression of

gene/protein

MYOZ2

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of AL117653 (DKFZp586C0224).
Formal Description
Interaction-ID: 37016

environment

high-fat diet

decreases_expression of

gene/protein

MITF

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of AL137597 (DKFZp434B2411).
Formal Description
Interaction-ID: 37017

environment

high-fat diet

decreases_expression of

gene/protein

TP53INP2

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of AK022297 (FLJ12235 fis).
Formal Description
Interaction-ID: 37018

environment

high-fat diet

decreases_expression of

gene/protein

RIC3

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of LOC51218 (NM_016417).
Formal Description
Interaction-ID: 37019

environment

high-fat diet

decreases_expression of

gene/protein

GLRX5

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of AL137363 (DKFZp434D1026).
Formal Description
Interaction-ID: 37020

environment

high-fat diet

decreases_expression of

gene/protein

RIF1

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of AL157476 (DKFZp761C082).
Formal Description
Interaction-ID: 37021

environment

high-fat diet

decreases_expression of

gene/protein

BTBD9

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of AB037743 (KIAA1322).
Formal Description
Interaction-ID: 37022

environment

high-fat diet

decreases_expression of

gene/protein

TBC1D14

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of rhodanese.
Formal Description
Interaction-ID: 37023

environment

high-fat diet

decreases_expression of

gene/protein

TST

Drugbank entries Show/Hide entries for TST
Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of AB046796 (KIAA1576).
Formal Description
Interaction-ID: 37024

environment

high-fat diet

decreases_expression of

gene/protein

VAT1L

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression ofpropionyl Coenzyme A carboxylase, beta polypeptide (PCCB), a nuclear gene encoding mitochondrial protein.
Formal Description
Interaction-ID: 37025

environment

high-fat diet

decreases_expression of

gene/protein

PCCB

Drugbank entries Show/Hide entries for PCCB
Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of galactose-1-phosphate uridylyltransferase (GALT).
Formal Description
Interaction-ID: 37026

environment

high-fat diet

decreases_expression of

gene/protein

GALT

Drugbank entries Show/Hide entries for GALT
Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of valosin-containing protein (VCP).
Formal Description
Interaction-ID: 37027

environment

high-fat diet

decreases_expression of

gene/protein

VCP

Drugbank entries Show/Hide entries for VCP
Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of NM_014056 (DKFZP564K247).
Formal Description
Interaction-ID: 37028

environment

high-fat diet

decreases_expression of

gene/protein

HIGD1A

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of the necdin (mouse) homolog (NDN).
Formal Description
Interaction-ID: 37029

environment

high-fat diet

decreases_expression of

gene/protein

NDN

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of adenylate kinase 1 (AK1), a nuclear gene encoding mitochondrial protein.
Formal Description
Interaction-ID: 37031

environment

high-fat diet

decreases_expression of

gene/protein

AK1

Drugbank entries Show/Hide entries for AK1
Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of interferon-responsive finger protein 1 long form.
Formal Description
Interaction-ID: 37032

environment

high-fat diet

decreases_expression of

gene/protein

TRIM6-TRIM34

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of eukaryotic translation initiation factor 1A (EIF1A).
Formal Description
Interaction-ID: 37033

environment

high-fat diet

decreases_expression of

gene/protein

EIF1AX

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of aminoacylase 1 (ACY1).
Formal Description
Interaction-ID: 37034

environment

high-fat diet

decreases_expression of

gene/protein

ACY1

Drugbank entries Show/Hide entries for ACY1
Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of thyroid receptor interacting protein 15 (TRIP15).
Formal Description
Interaction-ID: 37035

environment

high-fat diet

decreases_expression of

gene/protein

COPS2

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of docking protein 2, 56kD (DOK2).
Formal Description
Interaction-ID: 37036

environment

high-fat diet

decreases_expression of

gene/protein

DOK2

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of cyclic nucleotide gated channel beta 1 (CNGB1).
Formal Description
Interaction-ID: 37037

environment

high-fat diet

decreases_expression of

gene/protein

CNGB1

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of AL049471 (DKFZp586N012).
Formal Description
Interaction-ID: 37039

environment

high-fat diet

increases_expression of

gene/protein

ARID5B

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of hypothetical protein PRO0813 (PRO0813) (NM_018593).
Formal Description
Interaction-ID: 37040

environment

high-fat diet

increases_expression of

gene/protein

SLC16A10

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of small cellular 7 SK mRNA.
Formal Description
Interaction-ID: 37041

environment

high-fat diet

increases_expression of

gene/protein

RN7SK

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of TGFB inducible early growth response (TIEG).
Formal Description
Interaction-ID: 37043

environment

high-fat diet

increases_expression of

gene/protein

KLF10

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of hypothetical protein (HSPC228).
Formal Description
Interaction-ID: 37044

environment

high-fat diet

increases_expression of

gene/protein

VTA1

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of transferrin receptor (p90, CD71) (TFRC).
Formal Description
Interaction-ID: 37045

environment

high-fat diet

increases_expression of

gene/protein

TFRC

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of growth differentiation factor 1 (GDF1).
Formal Description
Interaction-ID: 37046

environment

high-fat diet

increases_expression of

gene/protein

GDF1

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of prostaglandin D2 synthase (21kD, brain) (PTGDS).
Formal Description
Interaction-ID: 37047

environment

high-fat diet

increases_expression of

gene/protein

PTGDS

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of hypothetical protein FLJ20084.
Formal Description
Interaction-ID: 37048

environment

high-fat diet

increases_expression of

gene/protein

QPCTL

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of carbonic anhydrase II (CA2).
Formal Description
Interaction-ID: 37049

environment

high-fat diet

increases_expression of

gene/protein

CA2

Drugbank entries Show/Hide entries for CA2
Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of epidermal growth factor (beta-urogastrone) (EGF).
Formal Description
Interaction-ID: 37050

environment

high-fat diet

increases_expression of

gene/protein

EGF

Drugbank entries Show/Hide entries for EGF
Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of interleukin-13 receptor soluble form.
Formal Description
Interaction-ID: 37051

environment

high-fat diet

increases_expression of

gene/protein

IL13RA1

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of AL050148 (DKFZp586G1520).
Formal Description
Interaction-ID: 37052

environment

high-fat diet

decreases_expression of

gene/protein

SNX1

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of chloride channel 1, skeletal muscle (CLCN1).
Formal Description
Interaction-ID: 37053

environment

high-fat diet

decreases_expression of

gene/protein

CLCN1

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of chloride channel 3 (CLCN3).
Formal Description
Interaction-ID: 37054

environment

high-fat diet

decreases_expression of

gene/protein

CLCN3

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of NM_017781 (DKFZP564K247 protein).
Formal Description
Interaction-ID: 37055

environment

high-fat diet

decreases_expression of

gene/protein

CYP2W1

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of NM_004170.
Formal Description
Interaction-ID: 37056

environment

high-fat diet

decreases_expression of

gene/protein

SLC1A1

Drugbank entries Show/Hide entries for SLC1A1
Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of uncharacterized hematopoietic stem/progenitor cells protein MDS032 (MDS032).
Formal Description
Interaction-ID: 37057

environment

high-fat diet

decreases_expression of

gene/protein

USE1

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of ficolin (collagen/fibrinogen domain-containing) 3 (Hakata antigen) (FCN3).
Formal Description
Interaction-ID: 37058

environment

high-fat diet

decreases_expression of

gene/protein

FCN3

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of carbonic anhydrase IV (CA4).
Formal Description
Interaction-ID: 37059

environment

high-fat diet

decreases_expression of

gene/protein

CA4

Drugbank entries Show/Hide entries for CA4
Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of ubiquitin-conjugating enzyme E2H (homologous to yeast UBC8) (UBE2H).
Formal Description
Interaction-ID: 37060

environment

high-fat diet

decreases_expression of

gene/protein

UBE2H

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of AK025657 (FLJ22004 fis).
Formal Description
Interaction-ID: 37061

environment

high-fat diet

decreases_expression of

gene/protein

SLC35F5

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of NM_014709 (KIAA0570).
Formal Description
Interaction-ID: 37062

environment

high-fat diet

decreases_expression of

gene/protein

USP34

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of NM_014752 (KIAA0102).
Formal Description
Interaction-ID: 37063

environment

high-fat diet

decreases_expression of

gene/protein

SPCS2

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of sulfotransferase family 2A, dehydroepiandrosterone (DHEA) -preferring, member 1 (SULT2A1).
Formal Description
Interaction-ID: 37064

environment

high-fat diet

decreases_expression of

gene/protein

SULT2A1

Drugbank entries Show/Hide entries for SULT2A1
Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of NM_014845 (KIAA0274).
Formal Description
Interaction-ID: 37065

environment

high-fat diet

decreases_expression of

gene/protein

FIG4

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of voltage-dependent anion channel 2 (VDAC2), a nuclear gene encoding mitochondrial protein.
Formal Description
Interaction-ID: 37066

environment

high-fat diet

increases_expression of

gene/protein

VDAC2

Drugbank entries Show/Hide entries for VDAC2
Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of AL161991 (DKFZp761C169).
Formal Description
Interaction-ID: 37067

environment

high-fat diet

increases_expression of

gene/protein

GPBP1

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of mRNA containing U19H snoRNA (AJ224166).
Formal Description
Interaction-ID: 37068

environment

high-fat diet

increases_expression of

gene/protein

MATR3

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of GTP-binding protein (rhoA) mRNA.
Formal Description
Interaction-ID: 37069

environment

high-fat diet

increases_expression of

gene/protein

RHOA

Drugbank entries Show/Hide entries for RHOA
Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of AB011152 (KIAA0580).
Formal Description
Interaction-ID: 37074

environment

high-fat diet

increases_expression of

gene/protein

ARAP2

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of MIB006 (C12orf6) (NM_020367).
Formal Description
Interaction-ID: 37075

environment

high-fat diet

increases_expression of

gene/protein

PARP11

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of AK023683 (FLJ13621 fis).
Formal Description
Interaction-ID: 37076

environment

high-fat diet

increases_expression of

gene/protein

CEP135

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of AK022872 (FLJ12810 fis).
Formal Description
Interaction-ID: 37078

environment

high-fat diet

increases_expression of

gene/protein

DCLRE1B

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of RecQ protein 5 (RECQ5).
Formal Description
Interaction-ID: 37079

environment

high-fat diet

increases_expression of

gene/protein

RECQL5

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of RecQ protein-like (DNA helicase Q1-like) (RECQL).
Formal Description
Interaction-ID: 37081

environment

high-fat diet

increases_expression of

gene/protein

RECQL

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of hypothetical protein FLJ10701 (FLJ10701).
Formal Description
Interaction-ID: 37082

environment

high-fat diet

increases_expression of

gene/protein

SBNO1

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression ofterminal deoxynucleotidyltransferase gene, exon 7.
Formal Description
Interaction-ID: 37083

environment

high-fat diet

increases_expression of

gene/protein

DNTT

Drugbank entries Show/Hide entries for DNTT
Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of bicaudal D (Drosophila) homolog 1 (BICD1).
Formal Description
Interaction-ID: 37084

environment

high-fat diet

increases_expression of

gene/protein

BICD1

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of endogenous retroviral family W, env(C7), member 1 (syncytin) (ERVWE1).
Formal Description
Interaction-ID: 37085

environment

high-fat diet

increases_expression of

gene/protein

ERVW-1

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of glycerol kinase testis specific 2.
Formal Description
Interaction-ID: 37086

environment

high-fat diet

increases_expression of

gene/protein

GK2

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of pregnancy-zone protein (PZP).
Formal Description
Interaction-ID: 37087

environment

high-fat diet

increases_expression of

gene/protein

PZP

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of AB033102 (KIAA1276).
Formal Description
Interaction-ID: 37088

environment

high-fat diet

increases_expression of

gene/protein

FAM184B

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of neuronal cell death-related protein (LOC51616).
Formal Description
Interaction-ID: 37089

environment

high-fat diet

increases_expression of

gene/protein

TAF9B

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of thiopurine S-methyltransferase (TPMT).
Formal Description
Interaction-ID: 37091

environment

high-fat diet

increases_expression of

gene/protein

TPMT

Drugbank entries Show/Hide entries for TPMT
Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of NM_016360 ((LOC51204).
Formal Description
Interaction-ID: 37092

environment

high-fat diet

increases_expression of

gene/protein

TACO1

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of NM_014873 (KIAA0205).
Formal Description
Interaction-ID: 37093

environment

high-fat diet

increases_expression of

gene/protein

LPGAT1

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of AB018310 (KIAA0767).
Formal Description
Interaction-ID: 37094

environment

high-fat diet

increases_expression of

gene/protein

GRAMD4

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of interferon, gamma-inducible protein 16 (IFI16).
Formal Description
Interaction-ID: 37096

environment

high-fat diet

increases_expression of

gene/protein

IFI16

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of LHX5 protein.
Formal Description
Interaction-ID: 37097

environment

high-fat diet

increases_expression of

gene/protein

LHX5

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of solute carrier family 12 (potassium/chloride transporters), member 7 (SLC12A7).
Formal Description
Interaction-ID: 37098

environment

high-fat diet

increases_expression of

gene/protein

SLC12A7

Drugbank entries Show/Hide entries for SLC12A7
Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of Era GTPase A protein (HERA-A).
Formal Description
Interaction-ID: 37099

environment

high-fat diet

increases_expression of

gene/protein

ERAL1

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of HSPC019 protein (HSPC019).
Formal Description
Interaction-ID: 37100

environment

high-fat diet

decreases_expression of

gene/protein

OSTM1

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of AK022850 (FLJ12788 fis).
Formal Description
Interaction-ID: 37101

environment

high-fat diet

decreases_expression of

gene/protein

TTC31

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of AF131855 (clone 25056 mRNA).
Formal Description
Interaction-ID: 37102

environment

high-fat diet

decreases_expression of

gene/protein

POLR1D

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of AK001228 (FLJ10366 fis).
Formal Description
Interaction-ID: 37103

environment

high-fat diet

decreases_expression of

gene/protein

UHRF1BP1

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of AK002150 (FLJ11288 fis).
Formal Description
Interaction-ID: 37104

environment

high-fat diet

decreases_expression of

gene/protein

GBP2

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of AL109818 (clone EUROIMAGE 191017).
Formal Description
Interaction-ID: 37105

environment

high-fat diet

decreases_expression of

gene/protein

SYNJ1

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of HSPC065 protein (HSPC065).
Formal Description
Interaction-ID: 37106

environment

high-fat diet

decreases_expression of

gene/protein

CCDC113

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of AK026571 (FLJ22918 fis).
Formal Description
Interaction-ID: 37107

environment

high-fat diet

decreases_expression of

gene/protein

SBF2

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of AK002173 (FLJ11311 fis).
Formal Description
Interaction-ID: 37108

environment

high-fat diet

decreases_expression of

gene/protein

YTHDF3

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of growth arrest-specific 1 (GAS1).
Formal Description
Interaction-ID: 37109

environment

high-fat diet

decreases_expression of

gene/protein

GAS1

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of candidate mediator of the p53-dependent G2 arrest (REPRIMO).
Formal Description
Interaction-ID: 37110

environment

high-fat diet

decreases_expression of

gene/protein

RPRM

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of fibrinogen silencer binding protein (FSBP).
Formal Description
Interaction-ID: 37112

environment

high-fat diet

decreases_expression of

gene/protein

RAD54B

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of AL137703 (DKFZp564P1772).
Formal Description
Interaction-ID: 37113

environment

high-fat diet

decreases_expression of

gene/protein

ZMYND8

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of fumarate hydratase (FH).
Formal Description
Interaction-ID: 37114

environment

high-fat diet

decreases_expression of

gene/protein

FH

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of microsomal glutathione S-transferase 2 (MGST2).
Formal Description
Interaction-ID: 37115

environment

high-fat diet

decreases_expression of

gene/protein

MGST2

Drugbank entries Show/Hide entries for MGST2
Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of geranylgeranyl diphosphate synthase 1 (GGPS1).
Formal Description
Interaction-ID: 37116

environment

high-fat diet

decreases_expression of

gene/protein

GGPS1

Drugbank entries Show/Hide entries for GGPS1
Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of hypothetical protein FLJ11342 (FLJ11342).
Formal Description
Interaction-ID: 37120

environment

high-fat diet

decreases_expression of

gene/protein

ABHD10

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of AK024244 (FLJ14182 fis).
Formal Description
Interaction-ID: 37121

environment

high-fat diet

increases_expression of

gene/protein

SLC25A34

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of hypothetical protein FLJ10803 (FLJ10803).
Formal Description
Interaction-ID: 37122

environment

high-fat diet

increases_expression of

gene/protein

COA1

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of AF086535 (clone ZE07G05).
Formal Description
Interaction-ID: 37124

environment

high-fat diet

increases_expression of

gene/protein

OSCP1

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of AK025686 (FLJ22033 fis).
Formal Description
Interaction-ID: 37125

environment

high-fat diet

increases_expression of

gene/protein

TBC1D31

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of AF088035 (clone ZC26G04).
Formal Description
Interaction-ID: 37127

environment

high-fat diet

increases_expression of

gene/protein

ATF6

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of GalNAc-T9 mRNA for UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase.
Formal Description
Interaction-ID: 37128

environment

high-fat diet

increases_expression of

gene/protein

GALNT9

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of fucosyltransferase 9 (alpha (1,3) fucosyltransferase) (FUT9).
Formal Description
Interaction-ID: 37129

environment

high-fat diet

increases_expression of

gene/protein

FUT9

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of hu-GlcAT-P mRNA for glucuronyltransferase.
Formal Description
Interaction-ID: 37130

environment

high-fat diet

increases_expression of

gene/protein

B3GAT1

Drugbank entries Show/Hide entries for B3GAT1
Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of zinc-finger protein in MEN1 region (MCG4).
Formal Description
Interaction-ID: 37131

environment

high-fat diet

increases_expression of

gene/protein

ZFPL1

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of procollagen C-endopeptidase enhancer 2 (PCOLCE2).
Formal Description
Interaction-ID: 37132

environment

high-fat diet

increases_expression of

gene/protein

PCOLCE2

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of GTP-binding protein (RHO6).
Formal Description
Interaction-ID: 37133

environment

high-fat diet

increases_expression of

gene/protein

RND1

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of bone morphogenetic protein 6 (BMP6).
Formal Description
Interaction-ID: 37134

environment

high-fat diet

increases_expression of

gene/protein

BMP6

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of D63487 (KIAA0153).
Formal Description
Interaction-ID: 37135

environment

high-fat diet

increases_expression of

gene/protein

TTLL12

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of hypothetical protein FLJ20241 (FLJ20241).
Formal Description
Interaction-ID: 37136

environment

high-fat diet

increases_expression of

gene/protein

CC2D1A

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of AK023060 (FLJ12998 fis).
Formal Description
Interaction-ID: 37137

environment

high-fat diet

increases_expression of

gene/protein

MTHFSD

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of PAC97K10, chromosome X, similar to heparan-sulphate 6-sulfotransferase.
Formal Description
Interaction-ID: 37138

environment

high-fat diet

increases_expression of

gene/protein

HS6ST2

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of interferon, gamma-inducible protein 30 (IFI30).
Formal Description
Interaction-ID: 37139

environment

high-fat diet

increases_expression of

gene/protein

IFI30

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of monokine induced by gamma interferon (MIG).
Formal Description
Interaction-ID: 37140

environment

high-fat diet

increases_expression of

gene/protein

CXCL9

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of UDP glycosyltransferase 2 family, polypeptide B10 (UGT2B10).
Formal Description
Interaction-ID: 37141

environment

high-fat diet

increases_expression of

gene/protein

UGT2B10

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of AL137519 (DKFZp434A1518).
Formal Description
Interaction-ID: 37142

environment

high-fat diet

increases_expression of

gene/protein

DYNC1I2

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of splicing factor, arginine/serine-rich 5 (SFRS5).
Formal Description
Interaction-ID: 37143

environment

high-fat diet

increases_expression of

gene/protein

SRSF5

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of MAGE-D4 (MAGED4).
Formal Description
Interaction-ID: 37144

environment

high-fat diet

increases_expression of

gene/protein

MAGED4

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of histone H2A.1b.
Formal Description
Interaction-ID: 37145

environment

high-fat diet

increases_expression of

gene/protein

H2AC11

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of potassium voltage-gated channel, shaker-related subfamily, member 3 (KCNA3).
Formal Description
Interaction-ID: 37146

environment

high-fat diet

increases_expression of

gene/protein

KCNA3

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of AB037770 (KIAA1349).
Formal Description
Interaction-ID: 37147

environment

high-fat diet

increases_expression of

gene/protein

ZNF624

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of hypothetical protein FLJ20637 (FLJ20637).
Formal Description
Interaction-ID: 37148

environment

high-fat diet

increases_expression of

gene/protein

HERC6

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of E2 small nucleolar RNA.
Formal Description
Interaction-ID: 37149

environment

high-fat diet

decreases_expression of

gene/protein

SNORA62

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of AK021722 (FLJ11660 fis).
Formal Description
Interaction-ID: 37150

environment

high-fat diet

decreases_expression of

gene/protein

AGPAT5

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of AK023224 (FLJ13162 fis).
Formal Description
Interaction-ID: 37151

environment

high-fat diet

decreases_expression of

gene/protein

LINC00574

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of U79249 (clone 23839).
Formal Description
Interaction-ID: 37152

environment

high-fat diet

decreases_expression of

gene/protein

SPICE1

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of heme oxygenase (decycling) 1 (HMOX1).
Formal Description
Interaction-ID: 37153

environment

high-fat diet

decreases_expression of

gene/protein

HMOX1

Drugbank entries Show/Hide entries for HMOX1
Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of purinergic receptor P2Y, G-protein coupled, 1 (P2RY1).
Formal Description
Interaction-ID: 37154

environment

high-fat diet

decreases_expression of

gene/protein

P2RY1

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of U79242 (clone 23560).
Formal Description
Interaction-ID: 37155

environment

high-fat diet

increases_expression of

gene/protein

GRM5

Drugbank entries Show/Hide entries for GRM5
Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I) (B3GAT3).
Formal Description
Interaction-ID: 37156

environment

high-fat diet

increases_expression of

gene/protein

B3GAT3

Drugbank entries Show/Hide entries for B3GAT3
Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of PPAR(gamma) angiopoietin related protein (PGAR).
Formal Description
Interaction-ID: 37157

environment

high-fat diet

increases_expression of

gene/protein

ANGPTL4

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of hypothetical protein FLJ20275 (FLJ20275).
Formal Description
Interaction-ID: 37158

environment

high-fat diet

increases_expression of

gene/protein

FNBP1L

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of AK024067 (FLJ14005 fis).
Formal Description
Interaction-ID: 37160

environment

high-fat diet

increases_expression of

gene/protein

PPP1R3B

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of GTP-binding protein RAB19B (RAB19B).
Formal Description
Interaction-ID: 37161

environment

high-fat diet

increases_expression of

gene/protein

RAB19

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of RAB interacting factor (RABIF).
Formal Description
Interaction-ID: 37162

environment

high-fat diet

increases_expression of

gene/protein

RABIF

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of putative prostate cancer tumor suppressor (N33).
Formal Description
Interaction-ID: 37163

environment

high-fat diet

increases_expression of

gene/protein

TUSC3

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of fibroblast growth factor 12B (FGF12B).
Formal Description
Interaction-ID: 37164

environment

high-fat diet

increases_expression of

gene/protein

FGF12

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1) (GOT1).
Formal Description
Interaction-ID: 37165

environment

high-fat diet

decreases_expression of

gene/protein

GOT1

Drugbank entries Show/Hide entries for GOT1
Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of guanine nucleotide exchange factor (ARHGEF6).
Formal Description
Interaction-ID: 37167

environment

high-fat diet

decreases_expression of

gene/protein

ARHGEF6

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of promyelocytic leukemia cell mRNA, clones pHH58 and pHH81.
Formal Description
Interaction-ID: 37168

environment

high-fat diet

decreases_expression of

gene/protein

TMSB4X

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of U00942 (clone A9A2BR17).
Formal Description
Interaction-ID: 37169

environment

high-fat diet

decreases_expression of

gene/protein

FUS

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of AK026728 (FLJ23075 fis).
Formal Description
Interaction-ID: 37170

environment

high-fat diet

decreases_expression of

gene/protein

AQP4

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of S-protein (X03168).
Formal Description
Interaction-ID: 37171

environment

high-fat diet

decreases_expression of

gene/protein

VTN

Drugbank entries Show/Hide entries for VTN
Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6 (17kD, B17) (NDUFB6).
Formal Description
Interaction-ID: 37173

environment

high-fat diet

decreases_expression of

gene/protein

NDUFB6

Drugbank entries Show/Hide entries for NDUFB6
Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of protein tyrosine phosphatase type IVA, member 3 (PTP4A3).
Formal Description
Interaction-ID: 37174

environment

high-fat diet

decreases_expression of

gene/protein

PTP4A3

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (SDHB), a nuclear gene encoding mitochondrial protein.
Formal Description
Interaction-ID: 37176

environment

high-fat diet

decreases_expression of

gene/protein

SDHB

Drugbank entries Show/Hide entries for SDHB
Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of AL137511 (DKFZp761M222).
Formal Description
Interaction-ID: 37177

environment

high-fat diet

decreases_expression of

gene/protein

COQ8A

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain (ACADM), a nuclear gene encoding mitochondrial product.
Formal Description
Interaction-ID: 37178

environment

high-fat diet

decreases_expression of

gene/protein

ACADM

Drugbank entries Show/Hide entries for ACADM
Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of 2,4-dienoyl CoA reductase 1, mitochondrial (DECR1).
Formal Description
Interaction-ID: 37179

environment

high-fat diet

decreases_expression of

gene/protein

DECR1

Drugbank entries Show/Hide entries for DECR1
Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of fatty-acid-Coenzyme A ligase, long-chain 1 (FACL1), a nuclear gene encoding mitochondrial protein.
Formal Description
Interaction-ID: 37181

environment

high-fat diet

decreases_expression of

gene/protein

ACSL1

Drugbank entries Show/Hide entries for ACSL1
Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of pyruvate dehydrogenase (lipoamide) beta (PDHB).
Formal Description
Interaction-ID: 37182

environment

high-fat diet

decreases_expression of

gene/protein

PDHB

Drugbank entries Show/Hide entries for PDHB
Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of glycogen synthase 1 (muscle) (GYS1).
Formal Description
Interaction-ID: 37184

environment

high-fat diet

decreases_expression of

gene/protein

GYS1

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of AL137631 (DKFZp434B205).
Formal Description
Interaction-ID: 37185

environment

high-fat diet

decreases_expression of

gene/protein

FBXW5

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of uncharacterized hematopoietic stem/progenitor cells protein MDS029 (MDS029).
Formal Description
Interaction-ID: 37186

environment

high-fat diet

decreases_expression of

gene/protein

CISD1

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein) (ITIH4).
Formal Description
Interaction-ID: 37187

environment

high-fat diet

decreases_expression of

gene/protein

ITIH4

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of mitogen-activated protein kinase kinase 3 (MAP2K3).
Formal Description
Interaction-ID: 37188

environment

high-fat diet

decreases_expression of

gene/protein

MAP2K3

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of calsequestrin 2, cardiac muscle (CASQ2).
Formal Description
Interaction-ID: 37189

environment

high-fat diet

decreases_expression of

gene/protein

CASQ2

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of acetylcholinesterase (YT blood group) (ACHE), transcript variant E4-E5.
Formal Description
Interaction-ID: 37190

environment

high-fat diet

decreases_expression of

gene/protein

ACHE

Drugbank entries Show/Hide entries for ACHE
Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of eukaryotic translation initiation factor 3, subunit 5 (epsilon, 47kD) (EIF3S5).
Formal Description
Interaction-ID: 37191

environment

high-fat diet

decreases_expression of

gene/protein

EIF3F

Comment The 3-day isoenergetic high-fat diet (HFD) significantly downregulated the expression of UDP-glucose pyrophosphorylase 2 (UGP2).
Formal Description
Interaction-ID: 37193

environment

high-fat diet

decreases_expression of

gene/protein

UGP2

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of ITBA1 gene (ITBA1).
Formal Description
Interaction-ID: 37194

environment

high-fat diet

increases_expression of

gene/protein

TMEM187

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of AK022090 (FLJ12028 fis).
Formal Description
Interaction-ID: 37195

environment

high-fat diet

increases_expression of

gene/protein

GUCY1A2

Drugbank entries Show/Hide entries for GUCY1A2
Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of a gene predicted from cDNA with a complete coding sequence (KIAA0105).
Formal Description
Interaction-ID: 37196

environment

high-fat diet

increases_expression of

gene/protein

WTAP

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of hypothetical protein DKFZp762F2011.
Formal Description
Interaction-ID: 37197

environment

high-fat diet

increases_expression of

gene/protein

DHX33

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3).
Formal Description
Interaction-ID: 37198

environment

high-fat diet

increases_expression of

gene/protein

PFKFB3

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of pyruvate dehydrogenase kinase, isoenzyme 4 (PDK4).
Formal Description
Interaction-ID: 37199

environment

high-fat diet

increases_expression of

gene/protein

PDK4

Drugbank entries Show/Hide entries for PDK4
Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of insulin-like growth factor binding protein 1 (IGFBP1).
Formal Description
Interaction-ID: 37200

environment

high-fat diet

increases_expression of

gene/protein

IGFBP1

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of MADS box transcription enhancer factor 2, polypeptide D (myocyte enhancer factor 2D) (MEF2D).
Formal Description
Interaction-ID: 37201

environment

high-fat diet

increases_expression of

gene/protein

MEF2D

Comment The 3-day isoenergetic high-fat diet (HFD) significantly upregulated the expression of apolipoprotein D (APOD).
Formal Description
Interaction-ID: 37202

environment

high-fat diet

increases_expression of

gene/protein

APOD