General Information:

Id: 3,762 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
HTC-IR hepatoma cell
Reference: Najib S and Sanchez-Margalet V(2005) Homocysteine thiolactone inhibits insulin-stimulated DNA and protein synthesis: possible role of mitogen-activated protein kinase (MAPK), glycogen synthase kinase-3 (GSK-3) and p70 S6K phosphorylation J. Mol. Endocrinol. 34: 119-126 [PMID: 15691882]

Interaction Information:

Comment Homocysteine thiolactone inhibits insulin-mediated activation of the MAPK pathway. If glutathione was added 5 min before the preincubation with homocysteine thiolactone, the effect of insulin on p44/42 MAPK phosphorylation was restored.
Formal Description
Interaction-ID: 36630

drug/chemical compound


increases_activity of

after homocysteine thiolactone incubation
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