General Information:

Id: 3,762 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
HTC-IR hepatoma cell
Reference: Najib S and Sanchez-Margalet V(2005) Homocysteine thiolactone inhibits insulin-stimulated DNA and protein synthesis: possible role of mitogen-activated protein kinase (MAPK), glycogen synthase kinase-3 (GSK-3) and p70 S6K phosphorylation J. Mol. Endocrinol. 34: 119-126 [PMID: 15691882]

Interaction Information:

Comment Insulin stimulated the phosphorylation of p70 S6K, and this effect was inhibited by preincubation with homocysteine thiolactone. Again, preincubation of cells with glutathione prevented the inhibitory effect of homocysteine thiolactone on insulin-mediated p70 S6K phosphorylation.
Formal Description
Interaction-ID: 36618

drug/chemical compound


increases_phosphorylation of



after homocysteine thiolactone incubation
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