General Information:

Id: 3,762 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
HTC-IR hepatoma cell
article
Reference: Najib S and Sanchez-Margalet V(2005) Homocysteine thiolactone inhibits insulin-stimulated DNA and protein synthesis: possible role of mitogen-activated protein kinase (MAPK), glycogen synthase kinase-3 (GSK-3) and p70 S6K phosphorylation J. Mol. Endocrinol. 34: 119-126 [PMID: 15691882]

Interaction Information:

Comment Glutathione restored the insulin-mediated phosphorylation of both isoforms (GSK-3alpha and GSK-3beta).
Formal Description
Interaction-ID: 36614

drug/chemical compound

Glutathione

increases_phosphorylation of

gene/protein

GSK3A

after homocysteine thiolactone incubation
Drugbank entries Show/Hide entries for Glutathione
Comment Glutathione restored the insulin-mediated phosphorylation of both isoforms (GSK-3alpha and GSK-3beta).
Formal Description
Interaction-ID: 36615

drug/chemical compound

Glutathione

increases_phosphorylation of

gene/protein

GSK3B

after homocysteine thiolactone incubation
Drugbank entries Show/Hide entries for Glutathione or GSK3B
Comment Insulin stimulated the phosphorylation of p70 S6K, and this effect was inhibited by preincubation with homocysteine thiolactone. Again, preincubation of cells with glutathione prevented the inhibitory effect of homocysteine thiolactone on insulin-mediated p70 S6K phosphorylation.
Formal Description
Interaction-ID: 36618

drug/chemical compound

Glutathione

increases_phosphorylation of

gene/protein

RPS6KB1

after homocysteine thiolactone incubation
Drugbank entries Show/Hide entries for Glutathione
Comment Homocysteine thiolactone inhibits insulin-mediated activation of the MAPK pathway. If glutathione was added 5 min before the preincubation with homocysteine thiolactone, the effect of insulin on p44/42 MAPK phosphorylation was restored.
Formal Description
Interaction-ID: 36630

drug/chemical compound

Glutathione

increases_activity of

after homocysteine thiolactone incubation
Drugbank entries Show/Hide entries for Glutathione