General Information:

Id: 3,762 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
HTC-IR hepatoma cell
Reference: Najib S and Sanchez-Margalet V(2005) Homocysteine thiolactone inhibits insulin-stimulated DNA and protein synthesis: possible role of mitogen-activated protein kinase (MAPK), glycogen synthase kinase-3 (GSK-3) and p70 S6K phosphorylation J. Mol. Endocrinol. 34: 119-126 [PMID: 15691882]

Interaction Information:

Comment Glutathione restored the insulin-mediated phosphorylation of both isoforms (GSK-3alpha and GSK-3beta).
Formal Description
Interaction-ID: 36614

drug/chemical compound


increases_phosphorylation of



after homocysteine thiolactone incubation
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