General Information:

Id: 3,761 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Azizi G and Mirshafiey A(2012) The potential role of proinflammatory and antiinflammatory cytokines in Alzheimer disease pathogenesis Immunopharmacol Immunotoxicol 34: 881-895 [PMID: 22970774]

Interaction Information:

Comment Advanced glycation endproducts (AGEs) accumulate on protein deposits including the beta-amyloid plaques in AD.
Formal Description
Interaction-ID: 36753

drug/chemical compound

Advanced glycation end-product

interacts (colocalizes) with

in Alzheimer disease
Comment AGEs induce the expression of a variety of proinflammatory markers including the TNF-alpha, MMPs and inducible nitric oxide (NO) synthase.
Formal Description
Interaction-ID: 36756

drug/chemical compound

Advanced glycation end-product

increases_expression of

gene/protein

TNF

Drugbank entries Show/Hide entries for TNF
Comment AGEs induce the expression of a variety of proinflammatory markers including the TNF-alpha, MMPs and inducible nitric oxide (NO) synthase.
Formal Description
Interaction-ID: 36757

drug/chemical compound

Advanced glycation end-product

increases_expression of

gene/protein

Matrix metallopeptidase

Comment AGEs induce the expression of a variety of proinflammatory markers including the TNF-alpha, MMPs and inducible nitric oxide (NO) synthase.
Formal Description
Interaction-ID: 36758

drug/chemical compound

Advanced glycation end-product

increases_expression of

gene/protein

NOS2

Drugbank entries Show/Hide entries for NOS2
Comment AGEs induces Abeta accumulation, impaired learning/memory, and neurotoxicity in an Abeta-rich environment.
Formal Description
Interaction-ID: 36759

drug/chemical compound

Advanced glycation end-product

increases_quantity of

Comment AGEs induces Abeta accumulation, impaired learning/memory, and neurotoxicity in an Abeta-rich environment.
Formal Description
Interaction-ID: 36761

drug/chemical compound

Advanced glycation end-product

decreases_activity of

Comment AGEs induces Abeta accumulation, impaired learning/memory, and neurotoxicity in an Abeta-rich environment.
Formal Description
Interaction-ID: 36762

drug/chemical compound

Advanced glycation end-product

increases_activity of

process

neuron death

in an Abeta-rich environment; via neurotoxicity.