General Information:

Id: 373
Diseases: Amyotrophic lateral sclerosis
Mus musculus
transgenic mouse, transfected with mutant human SOD1(G93A), injured by unilateral sciatic nerve avulsion
BTO:0000312 motoneuron
article
Reference: Martin LJ et al.(2005) Adult motor neuron apoptosis is mediated by nitric oxide and Fas death receptor linked by DNA damage and p53 activation J. Neurosci. 25: 6449-6459 [PMID: 16000635]

Interaction Information:

Comment In mutant SOD1 mice with sciatic nerve avulsion (SNA), the rate of motor neuron loss was faster compared with wt non-transgenic mice, and the accumulation of DNA damage in injured motor neurons was greater compared with wt non-transgenic mice.
Formal Description
Interaction-ID: 1526

gene/protein mutant

SOD1-p.G93A

increases_activity of