General Information:

Id: 3,717 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mus musculus
Reference: Yun KU et al.(2013) Plasma homocysteine level and hepatic sulfur amino acid metabolism in mice fed a high-fat diet Eur J Nutr 52: 127-134 [PMID: 22209966]

Interaction Information:

Comment The hepatic concentrations of major metabolites and products in the transsulfuration pathway were monitored in mice fed a high-fat diet for 12 weeks. S-adenosylhomocysteine (SAH) and taurine levels in the liver were elevated significantly, while that of S-adenosylmethionine (SAM) was reduced, in mice fed a high-fat diet. Hepatic total cysteine and homocysteine levels were decreased to 76 and 73%, respectively, of those in control mice. On the other hand, neither methionine nor total glutathione (GSH) levels in the liver were altered.
Formal Description
Interaction-ID: 36161


high-fat diet

NOT affects_quantity of

drug/chemical compound


in liver
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