General Information:

Id: 3,717 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mus musculus
male
article
Reference: Yun KU et al.(2013) Plasma homocysteine level and hepatic sulfur amino acid metabolism in mice fed a high-fat diet Eur J Nutr 52: 127-134 [PMID: 22209966]

Interaction Information:

Comment Plasma total homocysteine, cysteine, and glutathione (GSH) concentrations were determined in mice fed a high-fat diet for 12 weeks. Plasma total homocysteine level in mice fed a high-fat diet was increased to 157% of the level in control mice. On the other hand, the high-fat diet resulted in a 16 or 28% decrease in plasma total cysteine and GSH levels, respectively, relative to control mice.
Formal Description
Interaction-ID: 36140

environment

high-fat diet

decreases_quantity of

drug/chemical compound

Glutathione

in blood plasma
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Comment The hepatic concentrations of major metabolites and products in the transsulfuration pathway were monitored in mice fed a high-fat diet for 12 weeks. S-adenosylhomocysteine (SAH) and taurine levels in the liver were elevated significantly, while that of S-adenosylmethionine (SAM) was reduced, in mice fed a high-fat diet. Hepatic total cysteine and homocysteine levels were decreased to 76 and 73%, respectively, of those in control mice. On the other hand, neither methionine nor total glutathione (GSH) levels in the liver were altered.
Formal Description
Interaction-ID: 36161

environment

high-fat diet

NOT affects_quantity of

drug/chemical compound

Glutathione

in liver
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