General Information:

Id: 3,717
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mus musculus
male
article
Reference: Yun KU et al.(2013) Plasma homocysteine level and hepatic sulfur amino acid metabolism in mice fed a high-fat diet Eur J Nutr 52: 127-134 [PMID: 22209966]

Interaction Information:

Comment Neither plasma alanine aminotransferase (ALT) nor aspartate aminotransferase (AST) activities were altered in mice fed a high-fat diet.
Formal Description
Interaction-ID: 36101

environment

high-fat diet

NOT affects_activity of

gene/protein

GPT

in blood plasma
Drugbank entries Show/Hide entries for GPT
Comment Neither plasma alanine aminotransferase (ALT) nor aspartate aminotransferase (AST) activities were altered in mice fed a high-fat diet.
Formal Description
Interaction-ID: 36103

environment

high-fat diet

NOT affects_activity of

gene/protein

GOT

in blood plasma
Comment No significant difference in malondialdehyde (MDA) formation was observed between the control and high-fat diet groups.
Formal Description
Interaction-ID: 36104

environment

high-fat diet

NOT affects_quantity of

drug/chemical compound

Malonaldehyde

in liver
Drugbank entries Show/Hide entries for
Comment Neither plasma insulin nor glucose levels were affected by a high-fat diet On the other hand, plasma leptin level was significantly increased in mice fed a high-fat diet.
Formal Description
Interaction-ID: 36132

environment

high-fat diet

NOT affects_quantity of

drug/chemical compound

Glucose

in blood plasma
Comment Neither plasma insulin nor glucose levels were affected by a high-fat diet On the other hand, plasma leptin level was significantly increased in mice fed a high-fat diet.
Formal Description
Interaction-ID: 36135

environment

high-fat diet

NOT affects_quantity of

complex/PPI

Insulin

in blood plasma
Comment Neither plasma insulin nor glucose levels were affected by a high-fat diet On the other hand, plasma leptin level was significantly increased in mice fed a high-fat diet.
Formal Description
Interaction-ID: 36136

environment

high-fat diet

increases_quantity of

gene/protein

LEP

in blood plasma
Comment Plasma total homocysteine, cysteine, and glutathione (GSH) concentrations were determined in mice fed a high-fat diet for 12 weeks. Plasma total homocysteine level in mice fed a high-fat diet was increased to 157% of the level in control mice. On the other hand, the high-fat diet resulted in a 16 or 28% decrease in plasma total cysteine and GSH levels, respectively, relative to control mice.
Formal Description
Interaction-ID: 36138

environment

high-fat diet

increases_quantity of

drug/chemical compound

Homocysteine

in blood plasma
Comment Plasma total homocysteine, cysteine, and glutathione (GSH) concentrations were determined in mice fed a high-fat diet for 12 weeks. Plasma total homocysteine level in mice fed a high-fat diet was increased to 157% of the level in control mice. On the other hand, the high-fat diet resulted in a 16 or 28% decrease in plasma total cysteine and GSH levels, respectively, relative to control mice.
Formal Description
Interaction-ID: 36139

environment

high-fat diet

decreases_quantity of

drug/chemical compound

Cysteine

in blood plasma
Comment Plasma total homocysteine, cysteine, and glutathione (GSH) concentrations were determined in mice fed a high-fat diet for 12 weeks. Plasma total homocysteine level in mice fed a high-fat diet was increased to 157% of the level in control mice. On the other hand, the high-fat diet resulted in a 16 or 28% decrease in plasma total cysteine and GSH levels, respectively, relative to control mice.
Formal Description
Interaction-ID: 36140

environment

high-fat diet

decreases_quantity of

drug/chemical compound

Glutathione

in blood plasma
Drugbank entries Show/Hide entries for
Comment The hepatic concentrations of major metabolites and products in the transsulfuration pathway were monitored in mice fed a high-fat diet for 12 weeks. S-adenosylhomocysteine (SAH) and taurine levels in the liver were elevated significantly, while that of S-adenosylmethionine (SAM) was reduced, in mice fed a high-fat diet. Hepatic total cysteine and homocysteine levels were decreased to 76 and 73%, respectively, of those in control mice. On the other hand, neither methionine nor total glutathione (GSH) levels in the liver were altered.
Formal Description
Interaction-ID: 36144

environment

high-fat diet

increases_quantity of

drug/chemical compound

S-Adenosylhomocysteine

in liver
Comment The hepatic concentrations of major metabolites and products in the transsulfuration pathway were monitored in mice fed a high-fat diet for 12 weeks. S-adenosylhomocysteine (SAH) and taurine levels in the liver were elevated significantly, while that of S-adenosylmethionine (SAM) was reduced, in mice fed a high-fat diet. Hepatic total cysteine and homocysteine levels were decreased to 76 and 73%, respectively, of those in control mice. On the other hand, neither methionine nor total glutathione (GSH) levels in the liver were altered.
Formal Description
Interaction-ID: 36152

environment

high-fat diet

increases_quantity of

drug/chemical compound

Taurine

in liver
Comment The hepatic concentrations of major metabolites and products in the transsulfuration pathway were monitored in mice fed a high-fat diet for 12 weeks. S-adenosylhomocysteine (SAH) and taurine levels in the liver were elevated significantly, while that of S-adenosylmethionine (SAM) was reduced, in mice fed a high-fat diet. Hepatic total cysteine and homocysteine levels were decreased to 76 and 73%, respectively, of those in control mice. On the other hand, neither methionine nor total glutathione (GSH) levels in the liver were altered.
Formal Description
Interaction-ID: 36155

environment

high-fat diet

decreases_quantity of

drug/chemical compound

S-Adenosylmethionine

in liver
Drugbank entries Show/Hide entries for
Comment The hepatic concentrations of major metabolites and products in the transsulfuration pathway were monitored in mice fed a high-fat diet for 12 weeks. S-adenosylhomocysteine (SAH) and taurine levels in the liver were elevated significantly, while that of S-adenosylmethionine (SAM) was reduced, in mice fed a high-fat diet. Hepatic total cysteine and homocysteine levels were decreased to 76 and 73%, respectively, of those in control mice. On the other hand, neither methionine nor total glutathione (GSH) levels in the liver were altered.
Formal Description
Interaction-ID: 36157

environment

high-fat diet

decreases_quantity of

drug/chemical compound

Homocysteine

in liver
Comment The hepatic concentrations of major metabolites and products in the transsulfuration pathway were monitored in mice fed a high-fat diet for 12 weeks. S-adenosylhomocysteine (SAH) and taurine levels in the liver were elevated significantly, while that of S-adenosylmethionine (SAM) was reduced, in mice fed a high-fat diet. Hepatic total cysteine and homocysteine levels were decreased to 76 and 73%, respectively, of those in control mice. On the other hand, neither methionine nor total glutathione (GSH) levels in the liver were altered.
Formal Description
Interaction-ID: 36159

environment

high-fat diet

decreases_quantity of

drug/chemical compound

Cysteine

in liver
Comment The hepatic concentrations of major metabolites and products in the transsulfuration pathway were monitored in mice fed a high-fat diet for 12 weeks. S-adenosylhomocysteine (SAH) and taurine levels in the liver were elevated significantly, while that of S-adenosylmethionine (SAM) was reduced, in mice fed a high-fat diet. Hepatic total cysteine and homocysteine levels were decreased to 76 and 73%, respectively, of those in control mice. On the other hand, neither methionine nor total glutathione (GSH) levels in the liver were altered.
Formal Description
Interaction-ID: 36160

environment

high-fat diet

NOT affects_quantity of

drug/chemical compound

Methionine

in liver
Comment The hepatic concentrations of major metabolites and products in the transsulfuration pathway were monitored in mice fed a high-fat diet for 12 weeks. S-adenosylhomocysteine (SAH) and taurine levels in the liver were elevated significantly, while that of S-adenosylmethionine (SAM) was reduced, in mice fed a high-fat diet. Hepatic total cysteine and homocysteine levels were decreased to 76 and 73%, respectively, of those in control mice. On the other hand, neither methionine nor total glutathione (GSH) levels in the liver were altered.
Formal Description
Interaction-ID: 36161

environment

high-fat diet

NOT affects_quantity of

drug/chemical compound

Glutathione

in liver
Drugbank entries Show/Hide entries for
Comment In polyamine synthesis, SAM is also the source of a propylamine group for spermidine and spermine following its decarboxylation by SAM decarboxylase. To determine whether the decrease in hepatic SAM was associated with an increased utilization of SAM for polyamine synthesis, hepatic levels of polyamines, including putrescine, spermidine, and spermine, were determined. Although the hepatic putrescine produced from ornithine by ornithine decarboxylase was significantly increased by 70% in mice fed a high-fat diet compared with controls, hepatic spermidine and spermine were not significantly affected. These results suggest that decreased hepatic SAM levels could not be attributed to elevated utilization of SAM for polyamine synthesis.
Formal Description
Interaction-ID: 36162

environment

high-fat diet

increases_quantity of

drug/chemical compound

Putrescine

in liver
Drugbank entries Show/Hide entries for
Comment In polyamine synthesis, SAM is also the source of a propylamine group for spermidine and spermine following its decarboxylation by SAM decarboxylase. To determine whether the decrease in hepatic SAM was associated with an increased utilization of SAM for polyamine synthesis, hepatic levels of polyamines, including putrescine, spermidine, and spermine, were determined. Although the hepatic putrescine produced from ornithine by ornithine decarboxylase was significantly increased by 70% in mice fed a high-fat diet compared with controls, hepatic spermidine and spermine were not significantly affected. These results suggest that decreased hepatic SAM levels could not be attributed to elevated utilization of SAM for polyamine synthesis.
Formal Description
Interaction-ID: 36168

environment

high-fat diet

NOT affects_quantity of

drug/chemical compound

Spermidine

in liver
Drugbank entries Show/Hide entries for
Comment In polyamine synthesis, SAM is also the source of a propylamine group for spermidine and spermine following its decarboxylation by SAM decarboxylase. To determine whether the decrease in hepatic SAM was associated with an increased utilization of SAM for polyamine synthesis, hepatic levels of polyamines, including putrescine, spermidine, and spermine, were determined. Although the hepatic putrescine produced from ornithine by ornithine decarboxylase was significantly increased by 70% in mice fed a high-fat diet compared with controls, hepatic spermidine and spermine were not significantly affected. These results suggest that decreased hepatic SAM levels could not be attributed to elevated utilization of SAM for polyamine synthesis.
Formal Description
Interaction-ID: 36169

environment

high-fat diet

NOT affects_quantity of

drug/chemical compound

Spermine

in liver
Drugbank entries Show/Hide entries for
Comment Hepatic levels of methionine adenosyltransferase I/III, methionine synthase, methylene tetrahydrofolate reductase, and gamma-glutamylcysteine ligase catalytic subunit were unchanged. Obese mice showed elevated betaine-homocysteine methyltransferase and decreased cystathionine beta-synthase activities, although the quantities of these enzymes were unchanged.
Formal Description
Interaction-ID: 36170

environment

high-fat diet

NOT affects_quantity of

gene/protein

MAT1A

in liver
Drugbank entries Show/Hide entries for MAT1A
Comment Hepatic levels of methionine adenosyltransferase I/III, methionine synthase, methylene tetrahydrofolate reductase, and gamma-glutamylcysteine ligase catalytic subunit were unchanged. Obese mice showed elevated betaine-homocysteine methyltransferase and decreased cystathionine beta-synthase activities, although the quantities of these enzymes were unchanged.
Formal Description
Interaction-ID: 36171

environment

high-fat diet

NOT affects_quantity of

gene/protein

MTR

in liver
Drugbank entries Show/Hide entries for MTR
Comment Hepatic levels of methionine adenosyltransferase I/III, methionine synthase, methylene tetrahydrofolate reductase, and gamma-glutamylcysteine ligase catalytic subunit were unchanged. Obese mice showed elevated betaine-homocysteine methyltransferase and decreased cystathionine beta-synthase activities, although the quantities of these enzymes were unchanged.
Formal Description
Interaction-ID: 36172

environment

high-fat diet

NOT affects_quantity of

gene/protein

MTHFR

in liver
Drugbank entries Show/Hide entries for MTHFR
Comment Hepatic levels of methionine adenosyltransferase I/III, methionine synthase, methylene tetrahydrofolate reductase, and gamma-glutamylcysteine ligase catalytic subunit were unchanged. Obese mice showed elevated betaine-homocysteine methyltransferase and decreased cystathionine beta-synthase activities, although the quantities of these enzymes were unchanged.
Formal Description
Interaction-ID: 36173

environment

high-fat diet

NOT affects_quantity of

gene/protein

GCLC

in liver
Drugbank entries Show/Hide entries for GCLC
Comment Hepatic levels of methionine adenosyltransferase I/III, methionine synthase, methylene tetrahydrofolate reductase, and gamma-glutamylcysteine ligase catalytic subunit were unchanged. Obese mice showed elevated betaine-homocysteine methyltransferase and decreased cystathionine beta-synthase activities, although the quantities of these enzymes were unchanged.
Formal Description
Interaction-ID: 36174

environment

high-fat diet

NOT affects_quantity of

gene/protein

BHMT

in liver
Drugbank entries Show/Hide entries for BHMT
Comment Hepatic levels of methionine adenosyltransferase I/III, methionine synthase, methylene tetrahydrofolate reductase, and gamma-glutamylcysteine ligase catalytic subunit were unchanged. Obese mice showed elevated betaine-homocysteine methyltransferase and decreased cystathionine beta-synthase activities, although the quantities of these enzymes were unchanged.
Formal Description
Interaction-ID: 36175

environment

high-fat diet

increases_activity of

gene/protein

BHMT

in liver
Drugbank entries Show/Hide entries for BHMT
Comment Hepatic levels of methionine adenosyltransferase I/III, methionine synthase, methylene tetrahydrofolate reductase, and gamma-glutamylcysteine ligase catalytic subunit were unchanged. Obese mice showed elevated betaine-homocysteine methyltransferase and decreased cystathionine beta-synthase activities, although the quantities of these enzymes were unchanged.
Formal Description
Interaction-ID: 36176

environment

high-fat diet

NOT affects_quantity of

gene/protein

CBS

in liver
Drugbank entries Show/Hide entries for CBS
Comment Hepatic levels of methionine adenosyltransferase I/III, methionine synthase, methylene tetrahydrofolate reductase, and gamma-glutamylcysteine ligase catalytic subunit were unchanged. Obese mice showed elevated betaine-homocysteine methyltransferase and decreased cystathionine beta-synthase activities, although the quantities of these enzymes were unchanged.
Formal Description
Interaction-ID: 36177

environment

high-fat diet

decreases_activity of

gene/protein

CBS

in liver
Drugbank entries Show/Hide entries for CBS