General Information:

Id: 369 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Rattus norvegicus
BTO:0000759 liver
Reference: Kammoun HL et al.(2009) GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice J. Clin. Invest. 119: 1201-1215 [PMID: 19363290]

Interaction Information:

Comment Treatment of cultured hepatocytes with ER stress inducers for 1 h was followed by a decrease in the precursor form of SREBP-1c and a massive accumulation of nuclear SREBP-1c.
Formal Description
Interaction-ID: 1484

increases_quantity of

mRNA/protein variant


in liver