General Information:

Id: 3,699 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Cai H et al.(2012) Metabolic dysfunction in Alzheimers disease and related neurodegenerative disorders Curr Alzheimer Res 9: 5-17 [PMID: 22329649]

Interaction Information:

Comment The cyclooxygenase inhibitor Ibuprofen (iso-butyl-propanoic-phenolic acid), which can activate PPARG, has been demonstrated to significantly reduce amyloid pathology and reduce microglial-mediated inflammation in a mouse model of AD, potentially via PPARG signaling.
Formal Description
Interaction-ID: 35954

drug/chemical compound

Ibuprofen

decreases_activity of

in a mouse model of AD
Drugbank entries Show/Hide entries for Ibuprofen