General Information:

Id: 368 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Obesity - [OMIM]
Mus musculus
ob/+ mouse, ob/ob mouse
Reference: Kammoun HL et al.(2009) GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice J. Clin. Invest. 5: 1201-1215 [PMID: 19363290]

Interaction Information:

Comment Inhibition of ER stress by overexpression of GRP78 caused a 6-fold increase in ob/ob mice of the glucose infusion rate necessary to maintain euglycemia. This was secondary to a 40 % decrease in hepatic glucose production and a 69 % increase in glucose utilization rate, which suggests that both liver and peripheral tissues have improved insulin sensitivity. There was no such effect of GRP78 overexpression in ob/+ mice.
Formal Description
Interaction-ID: 1517



decreases_activity of

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