General Information:

Id: 368 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Obesity - [OMIM]
Mus musculus
male
ob/+ mouse, ob/ob mouse
article
Reference: Kammoun HL et al.(2009) GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice J. Clin. Invest. 5: 1201-1215 [PMID: 19363290]

Interaction Information:

Comment IRS-2-mediated insulin signaling was the main pathway improved by counteracting ER stress in obese animals.
Formal Description
Interaction-ID: 1510

decreases_activity of

gene/protein

IRS2