General Information:

Id: 368 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Obesity - [OMIM]
Mus musculus
male
ob/+ mouse, ob/ob mouse
article
Reference: Kammoun HL et al.(2009) GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice J. Clin. Invest. 5: 1201-1215 [PMID: 19363290]

Interaction Information:

Comment IRS-2-mediated insulin signaling was the main pathway improved by counteracting ER stress in obese animals.
Formal Description
Interaction-ID: 1510

decreases_activity of

gene/protein

IRS2

Comment Inhibition of ER stress by overexpression of GRP78 caused a 6-fold increase in ob/ob mice of the glucose infusion rate necessary to maintain euglycemia. This was secondary to a 40 % decrease in hepatic glucose production and a 69 % increase in glucose utilization rate, which suggests that both liver and peripheral tissues have improved insulin sensitivity. There was no such effect of GRP78 overexpression in ob/+ mice.
Formal Description
Interaction-ID: 1517

gene/protein

HSPA5

decreases_activity of

Drugbank entries Show/Hide entries for HSPA5
Comment The mature nuclear forms of the UPR transcription factors ATF6 and XBP-1 accumulated in the livers of ob/ob mice compared with ob/+ mice. In contrast, the amount of ATF6 precursor was reduced in the livers of ob/ob mice compared to ob/+ mice, showing that ATF6 was processed in ob/ob mice. Adenovirally mediated overexpression of GRP78 caused a major increase in the protein content of GRP78 in ob/+ and ob/ob mice and a strong decrease in ATF6 and XBP nuclear forms in ob/ob mice, demonstrating that ER stress was reduced in the livers of these animals.
Formal Description
Interaction-ID: 12606

organism model

ob/ob mouse

decreases_activity of

in liver
Comment IRS-2-mediated insulin signaling was the main pathway improved by counteracting ER stress in obese animals.
Formal Description
Interaction-ID: 12625

disease

Obesity

increases_activity of