General Information:

Id: 3,686 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
Reference: Liu Y et al.(2012) Fetal rat metabonome alteration by prenatal caffeine ingestion probably due to the increased circulatory glucocorticoid level and altered peripheral glucose and lipid metabolic pathways Toxicol. Appl. Pharmacol. 262: 205-216 [PMID: 22583948]

Interaction Information:

Comment For glucose metabolism, the elevated alpha- and beta-glucose as well as decreased lactic acid contents occurred in fetal plasma and amniotic fluid of high-dose caffeine group, and increased lactic acid content in low-dose caffeine group.
Formal Description
Interaction-ID: 35486


prenatal caffeine ingestion

affects_activity of

Comment Prenatal caffeine ingestion characteristically changes the fetal metabonome, which is probably attributed to the alterations of glucose and lipid metabolic pathways induced by increased circulatory glucocorticoid (GC), activated GC metabolism and enhanced glucocorticoid receptor (GR) expression in peripheral metabolic tissues.
Formal Description
Interaction-ID: 35493