General Information:

Id: 3,686 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
Reference: Liu Y et al.(2012) Fetal rat metabonome alteration by prenatal caffeine ingestion probably due to the increased circulatory glucocorticoid level and altered peripheral glucose and lipid metabolic pathways Toxicol. Appl. Pharmacol. 262: 205-216 [PMID: 22583948]

Interaction Information:

Comment The levels of 27 metabolites involved in the metabolic processes of glucose, lipid and protein in fetal plasma were significantly changed after prenatal caffeine ingestion. These changes are summarized as follows: (1) an increase of glucose level (alpha- and beta-glucose) as well as a decrease of lactate content; (2) a relative decrease of a majority of saturated and unsaturated fatty acid, triglycerides, acetone and beta-hydroxybutyrate concentrations in fetal plasma of high-dose caffeine group, an increase of HDL-cholesterol level in all caffeine groups, and a decrease of VLDL in high-dose caffeine group; (3) decreased creatinine in low-dose caffeine group, increased contents of amino acids including essential amino acid (i.e. tyrosine, tryptophan and phenylalanine), non-essential amino acid (glutamine) as well as protein catabolic products (i.e. creatine, N-acetylglycoproteins and lysyl albumin) in the high-dose caffeine group. Besides, higher concentrations of caffeine were detected in all caffeine-treated groups.
Formal Description
Interaction-ID: 35427


prenatal caffeine ingestion

increases_quantity of

drug/chemical compound


in fetal blood plasma
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