General Information:

Id: 3,671 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type I - [OMIM]
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Reference: Natella F and Scaccini C(2012) Role of coffee in modulation of diabetes risk Nutr. Rev. 70: 207-217 [PMID: 22458694]

Interaction Information:

Comment The vast amount of evidence on the protective role of coffee against the development of T2D is in contrast with several experimental observations indicating the adverse effect of caffeine on glucose metabolism. In fact, reduced insulin sensitivity and increased plasma levels of glucose were reported in healthy subjects after acute administration of caffeine (i.e., a single dose after an abstinence period).
Formal Description
Interaction-ID: 35178

drug/chemical compound


increases_activity of


decreased insulin sensitivity

after acute administration of caffeine
Drugbank entries Show/Hide entries for Caffeine