General Information:

Id: 3,671 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type I - [OMIM]
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mammalia
review
Reference: Natella F and Scaccini C(2012) Role of coffee in modulation of diabetes risk Nutr. Rev. 70: 207-217 [PMID: 22458694]

Interaction Information:

Comment The vast amount of evidence on the protective role of coffee against the development of T2D is in contrast with several experimental observations indicating the adverse effect of caffeine on glucose metabolism. In fact, reduced insulin sensitivity and increased plasma levels of glucose were reported in healthy subjects after acute administration of caffeine (i.e., a single dose after an abstinence period).
Formal Description
Interaction-ID: 35178

drug/chemical compound

Caffeine

increases_activity of

phenotype

decreased insulin sensitivity

after acute administration of caffeine
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Comment The vast amount of evidence on the protective role of coffee against the development of T2D is in contrast with several experimental observations indicating the adverse effect of caffeine on glucose metabolism. In fact, reduced insulin sensitivity and increased plasma levels of glucose were reported in healthy subjects after acute administration of caffeine (i.e., a single dose after an abstinence period).
Formal Description
Interaction-ID: 35179

drug/chemical compound

Caffeine

increases_activity of

phenotype

hyperglycemia

after acute administration of caffeine
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Comment In animal models, caffeine intake increased the thermogenesis of brown adipose tissue (upregulating the expression of uncoupling protein).
Formal Description
Interaction-ID: 35212

drug/chemical compound

Caffeine

increases_activity of

in brown adipose tissue
Drugbank entries Show/Hide entries for Caffeine
Comment In animal models, caffeine intake increased the thermogenesis of brown adipose tissue (upregulating the expression of uncoupling protein).
Formal Description
Interaction-ID: 35213

drug/chemical compound

Caffeine

increases_expression of

gene/protein

UCP1

in brown adipose tissue
Drugbank entries Show/Hide entries for Caffeine
Comment In animal models, caffeine intake increased the thermogenesis of brown adipose tissue (upregulating the expression of uncoupling protein).
Formal Description
Interaction-ID: 35214

drug/chemical compound

Caffeine

increases_expression of

gene/protein

UCP2

in brown adipose tissue
Drugbank entries Show/Hide entries for Caffeine
Comment In animal models, caffeine intake increased the thermogenesis of brown adipose tissue (upregulating the expression of uncoupling protein).
Formal Description
Interaction-ID: 35215

drug/chemical compound

Caffeine

increases_expression of

gene/protein

UCP3

in brown adipose tissue
Drugbank entries Show/Hide entries for Caffeine
Comment In humans, the regular consumption of caffeine increased energy expenditure and stimulated lipid oxidation. Some studies in humans suggested that caffeine consumption stimulates lipolysis. Finally, caffeine seems able to increase the sense of satiety.
Formal Description
Interaction-ID: 35216

drug/chemical compound

Caffeine

increases_activity of

Drugbank entries Show/Hide entries for Caffeine
Comment In humans, the regular consumption of caffeine increased energy expenditure and stimulated lipid oxidation. Some studies in humans suggested that caffeine consumption stimulates lipolysis. Finally, caffeine seems able to increase the sense of satiety.
Formal Description
Interaction-ID: 35217

drug/chemical compound

Caffeine

increases_activity of

process

lipid oxidation

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Comment In humans, the regular consumption of caffeine increased energy expenditure and stimulated lipid oxidation. Some studies in humans suggested that caffeine consumption stimulates lipolysis. Finally, caffeine seems able to increase the sense of satiety.
Formal Description
Interaction-ID: 35218

drug/chemical compound

Caffeine

increases_activity of

Drugbank entries Show/Hide entries for Caffeine
Comment In humans, the regular consumption of caffeine increased energy expenditure and stimulated lipid oxidation. Some studies in humans suggested that caffeine consumption stimulates lipolysis. Finally, caffeine seems able to increase the sense of satiety.
Formal Description
Interaction-ID: 35219

drug/chemical compound

Caffeine

increases_activity of

phenotype

increased sense of satiety

Drugbank entries Show/Hide entries for Caffeine
Comment An anti-inflammatory role was also suggested for caffeine, which, at high doses, can protect pancreatic beta cells from toxicity induced by streptozotocin in rats.
Formal Description
Interaction-ID: 35225

drug/chemical compound

Caffeine

decreases_activity of

Drugbank entries Show/Hide entries for Caffeine
Comment An anti-inflammatory role was also suggested for caffeine, which, at high doses, can protect pancreatic beta cells from toxicity induced by streptozotocin in rats.
Formal Description
Interaction-ID: 35226

drug/chemical compound

Caffeine

decreases_activity of

disease

Streptozocin-induced diabetes

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