General Information:

Id: 3,671
Diseases: Diabetes mellitus, type I - [OMIM]
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mammalia
review
Reference: Natella F and Scaccini C(2012) Role of coffee in modulation of diabetes risk Nutr. Rev. 70: 207-217 [PMID: 22458694]

Interaction Information:

Comment To date, about a dozen prospective studies and two meta-analysis studies indicate that regular and moderate consumption of coffee reduces the risk of T2D and that the association does not depend on race, gender, or geographic distribution of the study population.
Formal Description
Interaction-ID: 35142

environment

coffee consumption

decreases_activity of

if coffee consumption is regular and moderate
Comment Numerous epidemiological studies reported that coffee consumption is consistently associated with a lower prevalence of impaired glucose tolerance, hyperglycemia (fasting and after glucose load), hyperinsulinemia, and insulin sensitivity.
Formal Description
Interaction-ID: 35143

environment

coffee consumption

decreases_activity of

Comment Numerous epidemiological studies reported that coffee consumption is consistently associated with a lower prevalence of impaired glucose tolerance, hyperglycemia (fasting and after glucose load), hyperinsulinemia, and insulin sensitivity.
Formal Description
Interaction-ID: 35144

environment

coffee consumption

decreases_activity of

phenotype

hyperglycemia

Comment Numerous epidemiological studies reported that coffee consumption is consistently associated with a lower prevalence of impaired glucose tolerance, hyperglycemia (fasting and after glucose load), hyperinsulinemia, and insulin sensitivity.
Formal Description
Interaction-ID: 35145

environment

coffee consumption

decreases_activity of

Comment Numerous epidemiological studies reported that coffee consumption is consistently associated with a lower prevalence of impaired glucose tolerance, hyperglycemia (fasting and after glucose load), hyperinsulinemia, and insulin sensitivity.
Formal Description
Interaction-ID: 35146

environment

coffee consumption

decreases_activity of

phenotype

decreased insulin sensitivity

Comment Epidemiological studies indicated that consumption of caffeinated coffee is positively associated with plasma adiponectin levels both in healthy and in diabetic women. Adiponectin is a hormone that regulates the catabolism of glucose and insulin sensitivity. Adiponectin levels are reduced in diabetics, and thus adiponectin is considered protective against diabetes. These findings, however, have not yet been confirmed in other population groups.
Formal Description
Interaction-ID: 35147

environment

coffee consumption

decreases_activity of

Comment Epidemiological studies indicated that consumption of caffeinated coffee is positively associated with plasma adiponectin levels both in healthy and in diabetic women. Adiponectin is a hormone that regulates the catabolism of glucose and insulin sensitivity. Adiponectin levels are reduced in diabetics, and thus adiponectin is considered protective against diabetes. These findings, however, have not yet been confirmed in other population groups.
Formal Description
Interaction-ID: 35148

increases_activity of

Comment Epidemiological studies indicated that consumption of caffeinated coffee is positively associated with plasma adiponectin levels both in healthy and in diabetic women. Adiponectin is a hormone that regulates the catabolism of glucose and insulin sensitivity. Adiponectin levels are reduced in diabetics, and thus adiponectin is considered protective against diabetes. These findings, however, have not yet been confirmed in other population groups.
Formal Description
Interaction-ID: 35149

environment

coffee consumption

NOT affects_activity of

Comment Several epidemiological studies showed an inverse association between coffee consumption and markers of inflammation and endothelial dysfunction, such as soluble receptor of tumor necrosis factor-alpha, C-reactive protein, E-selectin, and soluble vascular cell adhesion molecule 1 in healthy, diabetic, and obese subjects. In conflict with these data, one study reported opposite results, showing a positive association between coffee consumption and markers of inflammation, and another study reported no correlation between coffee consumption and markers of inflammation.
Formal Description
Interaction-ID: 35150

environment

coffee consumption

decreases_activity of

Comment Several epidemiological studies showed an inverse association between coffee consumption and markers of inflammation and endothelial dysfunction, such as soluble receptor of tumor necrosis factor-alpha, C-reactive protein, E-selectin, and soluble vascular cell adhesion molecule 1 in healthy, diabetic, and obese subjects. In conflict with these data, one study reported opposite results, showing a positive association between coffee consumption and markers of inflammation, and another study reported no correlation between coffee consumption and markers of inflammation.
Formal Description
Interaction-ID: 35154

environment

coffee consumption

increases_activity of

Comment Several epidemiological studies showed an inverse association between coffee consumption and markers of inflammation and endothelial dysfunction, such as soluble receptor of tumor necrosis factor-alpha, C-reactive protein, E-selectin, and soluble vascular cell adhesion molecule 1 in healthy, diabetic, and obese subjects. In conflict with these data, one study reported opposite results, showing a positive association between coffee consumption and markers of inflammation, and another study reported no correlation between coffee consumption and markers of inflammation.
Formal Description
Interaction-ID: 35155

environment

coffee consumption

NOT affects_activity of

Comment Several epidemiological studies showed an inverse association between coffee consumption and markers of inflammation and endothelial dysfunction, such as soluble receptor of tumor necrosis factor-alpha, C-reactive protein, E-selectin, and soluble vascular cell adhesion molecule 1 in healthy, diabetic, and obese subjects. In conflict with these data, one study reported opposite results, showing a positive association between coffee consumption and markers of inflammation, and another study reported no correlation between coffee consumption and markers of inflammation.
Formal Description
Interaction-ID: 35156

environment

coffee consumption

decreases_quantity of

gene/protein

sTNFR2

Comment Several epidemiological studies showed an inverse association between coffee consumption and markers of inflammation and endothelial dysfunction, such as soluble receptor of tumor necrosis factor-alpha, C-reactive protein, E-selectin, and soluble vascular cell adhesion molecule 1 in healthy, diabetic, and obese subjects. In conflict with these data, one study reported opposite results, showing a positive association between coffee consumption and markers of inflammation, and another study reported no correlation between coffee consumption and markers of inflammation.
Formal Description
Interaction-ID: 35158

environment

coffee consumption

decreases_activity of

phenotype

increased circulating C-reactive protein level

Comment Several epidemiological studies showed an inverse association between coffee consumption and markers of inflammation and endothelial dysfunction, such as soluble receptor of tumor necrosis factor-alpha, C-reactive protein, E-selectin, and soluble vascular cell adhesion molecule 1 in healthy, diabetic, and obese subjects. In conflict with these data, one study reported opposite results, showing a positive association between coffee consumption and markers of inflammation, and another study reported no correlation between coffee consumption and markers of inflammation.
Formal Description
Interaction-ID: 35160

environment

coffee consumption

decreases_quantity of

gene/protein

SELE

Drugbank entries Show/Hide entries for SELE
Comment Several epidemiological studies showed an inverse association between coffee consumption and markers of inflammation and endothelial dysfunction, such as soluble receptor of tumor necrosis factor-alpha, C-reactive protein, E-selectin, and soluble vascular cell adhesion molecule 1 in healthy, diabetic, and obese subjects. In conflict with these data, one study reported opposite results, showing a positive association between coffee consumption and markers of inflammation, and another study reported no correlation between coffee consumption and markers of inflammation.
Formal Description
Interaction-ID: 35162

environment

coffee consumption

decreases_quantity of

gene/protein

VCAM1

Drugbank entries Show/Hide entries for VCAM1
Comment Epidemiological data indicate that the association of coffee consumption with the development of cardiovascular disease can vary according to the genetic characteristics of individuals. Polymorphisms in the CYP1A2 gene (a gene involved in the metabolism of caffeine) and in the COMT gene (a gene involved in the metabolism of catecholamines) are able to modify the association between coffee consumption and the risk of some pathological conditions, such as cardiovascular events and hypertension. A high level of coffee consumption was associated with an increased risk of these diseases only in individuals with a specific polymorphism (i.e., those with slow caffeine or catecholamine metabolism).
Formal Description
Interaction-ID: 35166

environment

coffee consumption

affects_activity of

disease

Cardiovascular disease

via polymorphisms in CYP1A2 and COMT
Comment Epidemiological data indicate that the association of coffee consumption with the development of cardiovascular disease can vary according to the genetic characteristics of individuals. Polymorphisms in the CYP1A2 gene (a gene involved in the metabolism of caffeine) and in the COMT gene (a gene involved in the metabolism of catecholamines) are able to modify the association between coffee consumption and the risk of some pathological conditions, such as cardiovascular events and hypertension. A high level of coffee consumption was associated with an increased risk of these diseases only in individuals with a specific polymorphism (i.e., those with slow caffeine or catecholamine metabolism).
Formal Description
Interaction-ID: 35168

gene/protein

CYP1A2

affects_activity of

process

caffeine metabolic process

Drugbank entries Show/Hide entries for CYP1A2
Comment Epidemiological data indicate that the association of coffee consumption with the development of cardiovascular disease can vary according to the genetic characteristics of individuals. Polymorphisms in the CYP1A2 gene (a gene involved in the metabolism of caffeine) and in the COMT gene (a gene involved in the metabolism of catecholamines) are able to modify the association between coffee consumption and the risk of some pathological conditions, such as cardiovascular events and hypertension. A high level of coffee consumption was associated with an increased risk of these diseases only in individuals with a specific polymorphism (i.e., those with slow caffeine or catecholamine metabolism).
Formal Description
Interaction-ID: 35169

gene/protein

COMT

affects_activity of

Drugbank entries Show/Hide entries for COMT
Comment Epidemiological data indicate that the association of coffee consumption with the development of cardiovascular disease can vary according to the genetic characteristics of individuals. Polymorphisms in the CYP1A2 gene (a gene involved in the metabolism of caffeine) and in the COMT gene (a gene involved in the metabolism of catecholamines) are able to modify the association between coffee consumption and the risk of some pathological conditions, such as cardiovascular events and hypertension. A high level of coffee consumption was associated with an increased risk of these diseases only in individuals with a specific polymorphism (i.e., those with slow caffeine or catecholamine metabolism).
Formal Description
Interaction-ID: 35171

process

caffeine metabolic process

affects_activity of

disease

Cardiovascular disease

via polymorphisms in CYP1A2
Comment Epidemiological data indicate that the association of coffee consumption with the development of cardiovascular disease can vary according to the genetic characteristics of individuals. Polymorphisms in the CYP1A2 gene (a gene involved in the metabolism of caffeine) and in the COMT gene (a gene involved in the metabolism of catecholamines) are able to modify the association between coffee consumption and the risk of some pathological conditions, such as cardiovascular events and hypertension. A high level of coffee consumption was associated with an increased risk of these diseases only in individuals with a specific polymorphism (i.e., those with slow caffeine or catecholamine metabolism).
Formal Description
Interaction-ID: 35173

affects_activity of

disease

Cardiovascular disease

via polymorphisms in COMT
Comment The possibility that coffee consumption is more protective against the development of T2D in some particular genotypes cannot be excluded. One epidemiological study has indicated that the association between coffee consumption and the risk of T2D varies depending on the serum levels of the enzyme gamma-glutamyl transferase. In particular, the association appeared to be stronger in those individuals who had higher levels of the enzyme. This indication is particularly interesting because high levels of gamma-glutamyl transferase are associated with risk factors closely related to diabetes (age, obesity, metabolic syndrome) and with diabetes itself. Thus, drinking coffee could better protect individuals at increased risk of developing diabetes.
Formal Description
Interaction-ID: 35175

gene/protein

GGT1

affects_activity of

environment

coffee consumption

Drugbank entries Show/Hide entries for GGT1
Comment The vast amount of evidence on the protective role of coffee against the development of T2D is in contrast with several experimental observations indicating the adverse effect of caffeine on glucose metabolism. In fact, reduced insulin sensitivity and increased plasma levels of glucose were reported in healthy subjects after acute administration of caffeine (i.e., a single dose after an abstinence period).
Formal Description
Interaction-ID: 35178

drug/chemical compound

Caffeine

increases_activity of

phenotype

decreased insulin sensitivity

after acute administration of caffeine
Drugbank entries Show/Hide entries for Caffeine
Comment The vast amount of evidence on the protective role of coffee against the development of T2D is in contrast with several experimental observations indicating the adverse effect of caffeine on glucose metabolism. In fact, reduced insulin sensitivity and increased plasma levels of glucose were reported in healthy subjects after acute administration of caffeine (i.e., a single dose after an abstinence period).
Formal Description
Interaction-ID: 35179

drug/chemical compound

Caffeine

increases_activity of

phenotype

hyperglycemia

after acute administration of caffeine
Drugbank entries Show/Hide entries for Caffeine
Comment Other components of coffee might reduce or even antagonize the negative effects of caffeine on glucose metabolism. This hypothesis seems to be confirmed by epidemiological studies that demonstrated a lower prevalence of hyperinsulinemia, an increased insulin sensitivity, a reduced risk of insulin resistance, and a lower plasma glucose level 2 h after glucose load in regular consumers of coffee.
Formal Description
Interaction-ID: 35180

environment

coffee consumption

decreases_activity of

disease

Insulin resistance

Comment Some authors studied the possibility that phenolic compounds in coffee were responsible for the antagonistic effect against caffeine. In animal models, consumption of chlorogenic acid (and/or its derivatives) or plant extracts rich in chlorogenic acid reduced fasting plasma glucose, increased sensitivity to insulin, and slowed the appearance of glucose in circulation after glucose load. In addition, it is known that some metabolites of chlorogenic acids (such as ferulic acid and isoferulic acid) also exert a hypoglycemic effect.
Formal Description
Interaction-ID: 35181

drug/chemical compound

Chlorogenate

decreases_activity of

phenotype

decreased insulin sensitivity

Comment Some authors studied the possibility that phenolic compounds in coffee were responsible for the antagonistic effect against caffeine. In animal models, consumption of chlorogenic acid (and/or its derivatives) or plant extracts rich in chlorogenic acid reduced fasting plasma glucose, increased sensitivity to insulin, and slowed the appearance of glucose in circulation after glucose load. In addition, it is known that some metabolites of chlorogenic acids (such as ferulic acid and isoferulic acid) also exert a hypoglycemic effect.
Formal Description
Interaction-ID: 35182

drug/chemical compound

Chlorogenate

decreases_activity of

phenotype

hyperglycemia

after fasting
Comment Some authors studied the possibility that phenolic compounds in coffee were responsible for the antagonistic effect against caffeine. In animal models, consumption of chlorogenic acid (and/or its derivatives) or plant extracts rich in chlorogenic acid reduced fasting plasma glucose, increased sensitivity to insulin, and slowed the appearance of glucose in circulation after glucose load. In addition, it is known that some metabolites of chlorogenic acids (such as ferulic acid and isoferulic acid) also exert a hypoglycemic effect.
Formal Description
Interaction-ID: 35183

drug/chemical compound

Ferulate

decreases_activity of

phenotype

hyperglycemia

Comment Some authors studied the possibility that phenolic compounds in coffee were responsible for the antagonistic effect against caffeine. In animal models, consumption of chlorogenic acid (and/or its derivatives) or plant extracts rich in chlorogenic acid reduced fasting plasma glucose, increased sensitivity to insulin, and slowed the appearance of glucose in circulation after glucose load. In addition, it is known that some metabolites of chlorogenic acids (such as ferulic acid and isoferulic acid) also exert a hypoglycemic effect.
Formal Description
Interaction-ID: 35184

drug/chemical compound

Isoferulic acid

decreases_activity of

phenotype

hyperglycemia

Comment Several mechanisms were proposed to explain how chlorogenic acid could affect glucose homeostasis. In an in vitro study conducted on vesicles of rat intestine membrane, chlorogenic acid reduced the intestinal absorption of glucose through inhibition of Na+-dependent glucose transporter. A study using the same experimental model demonstrated that caffeic acid has a weak inhibitory activity against sucrase activity (an enzyme involved in the digestion of carbohydrates). In in vitro studies conducted on rat and human liver microsomes, chlorogenic acid was able to inhibit glucose 6-phosphatase, a key enzyme in the production of glucose in the liver. Finally, in a cellular model, chlorogenic acid enhanced the uptake of glucose by myotubes through the increased expression of the glucose transporter GLUT4.
Formal Description
Interaction-ID: 35185

drug/chemical compound

Chlorogenate

decreases_activity of

Comment Several mechanisms were proposed to explain how chlorogenic acid could affect glucose homeostasis. In an in vitro study conducted on vesicles of rat intestine membrane, chlorogenic acid reduced the intestinal absorption of glucose through inhibition of Na+-dependent glucose transporter. A study using the same experimental model demonstrated that caffeic acid has a weak inhibitory activity against sucrase activity (an enzyme involved in the digestion of carbohydrates). In in vitro studies conducted on rat and human liver microsomes, chlorogenic acid was able to inhibit glucose 6-phosphatase, a key enzyme in the production of glucose in the liver. Finally, in a cellular model, chlorogenic acid enhanced the uptake of glucose by myotubes through the increased expression of the glucose transporter GLUT4.
Formal Description
Interaction-ID: 35186

drug/chemical compound

Caffeate

decreases_activity of

gene/protein

SI

Drugbank entries Show/Hide entries for SI
Comment Several mechanisms were proposed to explain how chlorogenic acid could affect glucose homeostasis. In an in vitro study conducted on vesicles of rat intestine membrane, chlorogenic acid reduced the intestinal absorption of glucose through inhibition of Na+-dependent glucose transporter. A study using the same experimental model demonstrated that caffeic acid has a weak inhibitory activity against sucrase activity (an enzyme involved in the digestion of carbohydrates). In in vitro studies conducted on rat and human liver microsomes, chlorogenic acid was able to inhibit glucose 6-phosphatase, a key enzyme in the production of glucose in the liver. Finally, in a cellular model, chlorogenic acid enhanced the uptake of glucose by myotubes through the increased expression of the glucose transporter GLUT4.
Formal Description
Interaction-ID: 35187

drug/chemical compound

Chlorogenate

decreases_activity of

complex/PPI

Glucose-6-phosphatase

Comment Several mechanisms were proposed to explain how chlorogenic acid could affect glucose homeostasis. In an in vitro study conducted on vesicles of rat intestine membrane, chlorogenic acid reduced the intestinal absorption of glucose through inhibition of Na+-dependent glucose transporter. A study using the same experimental model demonstrated that caffeic acid has a weak inhibitory activity against sucrase activity (an enzyme involved in the digestion of carbohydrates). In in vitro studies conducted on rat and human liver microsomes, chlorogenic acid was able to inhibit glucose 6-phosphatase, a key enzyme in the production of glucose in the liver. Finally, in a cellular model, chlorogenic acid enhanced the uptake of glucose by myotubes through the increased expression of the glucose transporter GLUT4.
Formal Description
Interaction-ID: 35188

drug/chemical compound

Chlorogenate

increases_expression of

gene/protein

SLC2A4

Comment In humans, decaffeinated coffee modified the postprandial secretion of the gastrointestinal hormones secreted in response to glucose absorption and involved in its metabolism (glucose-dependent insulinotropic polypeptide and glucagon-like peptide 1), suggesting that coffee may delay intestinal glucose uptake by shifting glucose absorption to a more distal region of the gastrointestinal tract.
Formal Description
Interaction-ID: 35204

environment

decaffeinated coffee consumption

affects_activity of

process

GLP1 secretion

Comment In humans, decaffeinated coffee modified the postprandial secretion of the gastrointestinal hormones secreted in response to glucose absorption and involved in its metabolism (glucose-dependent insulinotropic polypeptide and glucagon-like peptide 1), suggesting that coffee may delay intestinal glucose uptake by shifting glucose absorption to a more distal region of the gastrointestinal tract.
Formal Description
Interaction-ID: 35205

environment

decaffeinated coffee consumption

affects_activity of

process

GIP secretion

Comment In humans, decaffeinated coffee modified the postprandial secretion of the gastrointestinal hormones secreted in response to glucose absorption and involved in its metabolism (glucose-dependent insulinotropic polypeptide and glucagon-like peptide 1), suggesting that coffee may delay intestinal glucose uptake by shifting glucose absorption to a more distal region of the gastrointestinal tract.
Formal Description
Interaction-ID: 35206

environment

decaffeinated coffee consumption

affects_activity of

process

gastrointestinal hormone secretion

Comment In an experimental study conducted in cellular and animal models, ferulic acid (a metabolite of chlorogenic acid) stimulated insulin secretion by pancreatic beta cells, and this effect influenced plasma glucose concentration.
Formal Description
Interaction-ID: 35207

drug/chemical compound

Ferulate

increases_activity of

Comment An effect on glucose metabolism was also suggested for the coffee compound trigonelline. Trigonelline is a precursor of vitamin B3 and represents about 1% of the dry weight of roasted coffee beans. An experimental study conducted in an animal model showed that trigonelline exerts a hypoglycemic effect. However, these data have not been confirmed in human studies; in fact, supplementation with high doses of trigonelline in humans had no effect on glucose metabolism, except in the very short term (15 min after glucose load).
Formal Description
Interaction-ID: 35208

drug/chemical compound

N-Methylnicotinate

decreases_activity of

phenotype

hyperglycemia

in an animal model
Comment An effect on glucose metabolism was also suggested for the coffee compound trigonelline. Trigonelline is a precursor of vitamin B3 and represents about 1% of the dry weight of roasted coffee beans. An experimental study conducted in an animal model showed that trigonelline exerts a hypoglycemic effect. However, these data have not been confirmed in human studies; in fact, supplementation with high doses of trigonelline in humans had no effect on glucose metabolism, except in the very short term (15 min after glucose load).
Formal Description
Interaction-ID: 35209

drug/chemical compound

N-Methylnicotinate

NOT affects_activity of

phenotype

hyperglycemia

in humans
Comment Coffee is rather rich in magnesium. Several studies showed that magnesium may have a positive effect on glucose metabolism by increasing insulin sensitivity. However, this mechanism does not seem to be confirmed by epidemiological studies on the relationship between coffee and T2D; in fact, after adjusting for consumption of magnesium, the inverse association between coffee consumption and diabetes risk persists.
Formal Description
Interaction-ID: 35210

drug/chemical compound

Mg2+

increases_activity of

Comment In animal models, caffeine intake increased the thermogenesis of brown adipose tissue (upregulating the expression of uncoupling protein).
Formal Description
Interaction-ID: 35212

drug/chemical compound

Caffeine

increases_activity of

in brown adipose tissue
Drugbank entries Show/Hide entries for Caffeine
Comment In animal models, caffeine intake increased the thermogenesis of brown adipose tissue (upregulating the expression of uncoupling protein).
Formal Description
Interaction-ID: 35213

drug/chemical compound

Caffeine

increases_expression of

gene/protein

UCP1

in brown adipose tissue
Drugbank entries Show/Hide entries for Caffeine
Comment In animal models, caffeine intake increased the thermogenesis of brown adipose tissue (upregulating the expression of uncoupling protein).
Formal Description
Interaction-ID: 35214

drug/chemical compound

Caffeine

increases_expression of

gene/protein

UCP2

in brown adipose tissue
Drugbank entries Show/Hide entries for Caffeine
Comment In animal models, caffeine intake increased the thermogenesis of brown adipose tissue (upregulating the expression of uncoupling protein).
Formal Description
Interaction-ID: 35215

drug/chemical compound

Caffeine

increases_expression of

gene/protein

UCP3

in brown adipose tissue
Drugbank entries Show/Hide entries for Caffeine
Comment In humans, the regular consumption of caffeine increased energy expenditure and stimulated lipid oxidation. Some studies in humans suggested that caffeine consumption stimulates lipolysis. Finally, caffeine seems able to increase the sense of satiety.
Formal Description
Interaction-ID: 35216

drug/chemical compound

Caffeine

increases_activity of

Drugbank entries Show/Hide entries for Caffeine
Comment In humans, the regular consumption of caffeine increased energy expenditure and stimulated lipid oxidation. Some studies in humans suggested that caffeine consumption stimulates lipolysis. Finally, caffeine seems able to increase the sense of satiety.
Formal Description
Interaction-ID: 35217

drug/chemical compound

Caffeine

increases_activity of

process

lipid oxidation

Drugbank entries Show/Hide entries for Caffeine
Comment In humans, the regular consumption of caffeine increased energy expenditure and stimulated lipid oxidation. Some studies in humans suggested that caffeine consumption stimulates lipolysis. Finally, caffeine seems able to increase the sense of satiety.
Formal Description
Interaction-ID: 35218

drug/chemical compound

Caffeine

increases_activity of

Drugbank entries Show/Hide entries for Caffeine
Comment In humans, the regular consumption of caffeine increased energy expenditure and stimulated lipid oxidation. Some studies in humans suggested that caffeine consumption stimulates lipolysis. Finally, caffeine seems able to increase the sense of satiety.
Formal Description
Interaction-ID: 35219

drug/chemical compound

Caffeine

increases_activity of

phenotype

increased sense of satiety

Drugbank entries Show/Hide entries for Caffeine
Comment In overweight subjects, a chlorogenic-acid-rich supplement was significantly more effective than placebo in helping to reduce body weight, and the consumption of coffee enriched with chlorogenic acid for 3 months resulted in a significant reduction in body weight and fat mass.
Formal Description
Interaction-ID: 35220

drug/chemical compound

Chlorogenate

increases_activity of

phenotype

weight loss

Comment Coffee is extremely rich in antioxidants, particularly phenolic compounds (mainly chlorogenic acids) and melanoidins; in addition, caffeine shows a slight antioxidant activity. Brewed coffee possesses a very high antioxidant capacity in vitro and is one of the major contributors to the antioxidant capacity of the diet in many countries. It is noteworthy that coffee antioxidants are bioavailable; in fact, several animal and human studies demonstrated that coffee consumption increases plasma antioxidant capacity.
Formal Description
Interaction-ID: 35221

environment

coffee consumption

decreases_activity of

Comment The antioxidants in coffee could protect pancreatic beta cells from oxidative stress. An experimental study conducted in an animal model showed that 24-day consumption of the lignan secoisolariciresinol diglucoside (a coffee antioxidant) can reduce by 75% the development of diabetes induced by streptozotocin.
Formal Description
Interaction-ID: 35222

drug/chemical compound

Secoisolariciresinol diglucoside

decreases_activity of

Comment The antioxidants in coffee could protect pancreatic beta cells from oxidative stress. An experimental study conducted in an animal model showed that 24-day consumption of the lignan secoisolariciresinol diglucoside (a coffee antioxidant) can reduce by 75% the development of diabetes induced by streptozotocin.
Formal Description
Interaction-ID: 35223

drug/chemical compound

Secoisolariciresinol diglucoside

decreases_activity of

disease

Streptozocin-induced diabetes

Comment An excessive action of glucocorticoids seems to play an important role in the pathogenesis of diabetes and metabolic syndrome. One experimental study conducted on a cellular model showed that coffee may inhibit the reactivation of glucocorticoids by inhibiting 11beta-hydroxysteroid dehydrogenase.
Formal Description
Interaction-ID: 35224

environment

coffee consumption

decreases_activity of

gene/protein

HSD11B1

Drugbank entries Show/Hide entries for HSD11B1
Comment An anti-inflammatory role was also suggested for caffeine, which, at high doses, can protect pancreatic beta cells from toxicity induced by streptozotocin in rats.
Formal Description
Interaction-ID: 35225

drug/chemical compound

Caffeine

decreases_activity of

Drugbank entries Show/Hide entries for Caffeine
Comment An anti-inflammatory role was also suggested for caffeine, which, at high doses, can protect pancreatic beta cells from toxicity induced by streptozotocin in rats.
Formal Description
Interaction-ID: 35226

drug/chemical compound

Caffeine

decreases_activity of

disease

Streptozocin-induced diabetes

Drugbank entries Show/Hide entries for Caffeine