General Information:

Id: 3,662
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
article
Reference: Owen JB et al.(2009) Proteomics-determined differences in the concanavalin-A-fractionated proteome of hippocampus and inferior parietal lobule in subjects with Alzheimers disease and mild cognitive impairment: implications for progression of AD J. Proteome Res. 8: 471-482 [PMID: 19072283]

Interaction Information:

Comment Proteins found in AD hippocampus with altered expression are glutamate dehydrogenase (GDH), glial fibrillary acidic protein (GFAP), tropomyosin 3 (TPM3), Rab GDP-dissociation inhibitor XAP-4 (XAP4), and heat shock protein 90 (HSP90). XAP4 and HSP90 have decreased levels, while GDH, GFAP, and TPM3 levels are increased.
Formal Description
Interaction-ID: 35016

increases_expression of

gene/protein

GLUD1

in AD hippocampus
Drugbank entries Show/Hide entries for GLUD1
Comment Proteins found with increased levels in AD IPL (inferior parietal lobule) are alpha-enolase, gamma-enolase, and XAP-4.
Formal Description
Interaction-ID: 35017

increases_expression of

gene/protein

ENO1

in AD IPL (inferior parietal lobule)
Comment MCI hippocampal proteins with altered levels are dihydropyrimidase-2 (DRP2), glucose-regulated protein 78 (GRP-78), protein phosphatase related protein Sds-22 (Sds22), and GFAP and the only protein found with altered levels in MCI IPL was beta-synuclein. GRP78 and DRP2 have decreased levels.
Formal Description
Interaction-ID: 35018

phenotype

mild cognitive impairment

decreases_expression of

gene/protein

DRP2

in MCI hippocampus
Comment Proteins found in AD hippocampus with altered expression are glutamate dehydrogenase (GDH), glial fibrillary acidic protein (GFAP), tropomyosin 3 (TPM3), Rab GDP-dissociation inhibitor XAP-4 (XAP4), and heat shock protein 90 (HSP90). XAP4 and HSP90 have decreased levels, while GDH, GFAP, and TPM3 levels are increased.
Formal Description
Interaction-ID: 35032

increases_expression of

gene/protein

GFAP

in AD hippocampus
Comment Proteins found in AD hippocampus with altered expression are glutamate dehydrogenase (GDH), glial fibrillary acidic protein (GFAP), tropomyosin 3 (TPM3), Rab GDP-dissociation inhibitor XAP-4 (XAP4), and heat shock protein 90 (HSP90). XAP4 and HSP90 have decreased levels, while GDH, GFAP, and TPM3 levels are increased.
Formal Description
Interaction-ID: 35033

increases_expression of

gene/protein

TPM3

in AD hippocampus
Comment Proteins found in AD hippocampus with altered expression are glutamate dehydrogenase (GDH), glial fibrillary acidic protein (GFAP), tropomyosin 3 (TPM3), Rab GDP-dissociation inhibitor XAP-4 (XAP4), and heat shock protein 90 (HSP90). XAP4 and HSP90 have decreased levels, while GDH, GFAP, and TPM3 levels are increased.
Formal Description
Interaction-ID: 35034

decreases_expression of

gene/protein

POLR2E

in AD hippocampus
Comment Proteins found in AD hippocampus with altered expression are glutamate dehydrogenase (GDH), glial fibrillary acidic protein (GFAP), tropomyosin 3 (TPM3), Rab GDP-dissociation inhibitor XAP-4 (XAP4), and heat shock protein 90 (HSP90). XAP4 and HSP90 have decreased levels, while GDH, GFAP, and TPM3 levels are increased.
Formal Description
Interaction-ID: 35035

decreases_expression of

gene/protein

HSP90AA1

in AD hippocampus
Drugbank entries Show/Hide entries for HSP90AA1
Comment Proteins found with increased levels in AD IPL (inferior parietal lobule) are alpha-enolase, gamma-enolase, and XAP-4.
Formal Description
Interaction-ID: 35036

increases_expression of

gene/protein

ENO2

in AD IPL (inferior parietal lobule)
Drugbank entries Show/Hide entries for ENO2
Comment Proteins found with increased levels in AD IPL (inferior parietal lobule) are alpha-enolase, gamma-enolase, and XAP-4.
Formal Description
Interaction-ID: 35037

increases_expression of

gene/protein

POLR2E

in AD IPL (inferior parietal lobule)
Comment MCI hippocampal proteins with altered levels are dihydropyrimidase-2 (DRP2), glucose-regulated protein 78 (GRP-78), protein phosphatase related protein Sds-22 (Sds22), and GFAP and the only protein found with altered levels in MCI IPL was beta-synuclein. GRP78 and DRP2 have decreased levels.
Formal Description
Interaction-ID: 35039

phenotype

mild cognitive impairment

decreases_expression of

gene/protein

HSPA5

in MCI hippocampus
Drugbank entries Show/Hide entries for HSPA5
Comment MCI hippocampal proteins with altered levels are dihydropyrimidase-2 (DRP2), glucose-regulated protein 78 (GRP-78), protein phosphatase related protein Sds-22 (Sds22 / PPP1R7), and GFAP and the only protein found with altered levels in MCI IPL was beta-synuclein. Sds-22 and GFAP levels are increased.
Formal Description
Interaction-ID: 35040

phenotype

mild cognitive impairment

increases_expression of

gene/protein

PPP1R7

in MCI hippocampus
Comment MCI hippocampal proteins with altered levels are dihydropyrimidase-2 (DRP2), glucose-regulated protein 78 (GRP-78), protein phosphatase related protein Sds-22 (Sds22), and GFAP and the only protein found with altered levels in MCI IPL was beta-synuclein. Sds-22 and GFAP levels are increased.
Formal Description
Interaction-ID: 35047

phenotype

mild cognitive impairment

increases_expression of

gene/protein

GFAP

in MCI hippocampus
Comment MCI hippocampal proteins with altered levels are dihydropyrimidase-2 (DRP2), glucose-regulated protein 78 (GRP-78), protein phosphatase related protein Sds-22 (Sds22), and GFAP and the only protein found with altered levels in MCI IPL was beta-synuclein (with a decreased level).
Formal Description
Interaction-ID: 35048

phenotype

mild cognitive impairment

decreases_expression of

gene/protein

SNCB

in MCI IPL (inferior parietal lobule)
Comment Con-A-associated brain proteins in MCI: DRP2, GRP-78, SDS22, GFAP, SNCB.
Formal Description
Interaction-ID: 35055

drug/chemical compound

Concanavalin-A

interacts (colocalizes) with

gene/protein

DRP2

in MCI
Comment Con-A-associated brain proteins in AD: GDH/GLUD1, GFAP, HSP90, TPM3, XAP4, ENO1, ENO2.
Formal Description
Interaction-ID: 35056

drug/chemical compound

Concanavalin-A

interacts (colocalizes) with

gene/protein

GLUD1

in AD
Drugbank entries Show/Hide entries for GLUD1
Comment The early stages of memory loss associated with AD have been studied in a condition known as amnestic mild cognitive impairment (MCI), arguably the earliest form of AD.
Formal Description
Interaction-ID: 35059

increases_activity of

phenotype

mild cognitive impairment

early stage of memory loss associated with AD
Comment Con-A-associated brain proteins in MCI: DRP2, GRP-78/HSPA5, SDS22, GFAP, SNCB.
Formal Description
Interaction-ID: 35063

drug/chemical compound

Concanavalin-A

interacts (colocalizes) with

gene/protein

HSPA5

in MCI
Drugbank entries Show/Hide entries for HSPA5
Comment Con-A-associated brain proteins in MCI: DRP2, GRP-78, SDS22/PPP1R7, GFAP, SNCB.
Formal Description
Interaction-ID: 35064

drug/chemical compound

Concanavalin-A

interacts (colocalizes) with

gene/protein

PPP1R7

in MCI
Comment Con-A-associated brain proteins in MCI: DRP2, GRP-78, SDS22, GFAP, SNCB.
Formal Description
Interaction-ID: 35065

drug/chemical compound

Concanavalin-A

interacts (colocalizes) with

gene/protein

GFAP

in MCI
Comment Con-A-associated brain proteins in MCI: DRP2, GRP-78, SDS22, GFAP, SNCB.
Formal Description
Interaction-ID: 35066

drug/chemical compound

Concanavalin-A

interacts (colocalizes) with

gene/protein

SNCB

in MCI
Comment Con-A-associated brain proteins in AD: GDH, GFAP, HSP90, TPM3, XAP4, ENO1, ENO2.
Formal Description
Interaction-ID: 35067

drug/chemical compound

Concanavalin-A

interacts (colocalizes) with

gene/protein

GFAP

in AD
Comment Con-A-associated brain proteins in AD: GDH, GFAP, HSP90, TPM3, XAP4, ENO1, ENO2.
Formal Description
Interaction-ID: 35068

drug/chemical compound

Concanavalin-A

interacts (colocalizes) with

gene/protein

HSP90AA1

in AD
Drugbank entries Show/Hide entries for HSP90AA1
Comment Con-A-associated brain proteins in AD: GDH, GFAP, HSP90, TPM3, XAP4, ENO1, ENO2.
Formal Description
Interaction-ID: 35069

drug/chemical compound

Concanavalin-A

interacts (colocalizes) with

gene/protein

TPM3

in AD
Comment Con-A-associated brain proteins in AD: GDH, GFAP, HSP90, TPM3, XAP4/POLR2E, ENO1, ENO2.
Formal Description
Interaction-ID: 35070

drug/chemical compound

Concanavalin-A

interacts (colocalizes) with

gene/protein

POLR2E

in AD
Comment Con-A-associated brain proteins in AD: GDH, GFAP, HSP90, TPM3, XAP4, ENO1, ENO2.
Formal Description
Interaction-ID: 35071

drug/chemical compound

Concanavalin-A

interacts (colocalizes) with

gene/protein

ENO1

in AD
Comment Con-A-associated brain proteins in AD: GDH, GFAP, HSP90, TPM3, XAP4, ENO1, ENO2.
Formal Description
Interaction-ID: 35072

drug/chemical compound

Concanavalin-A

interacts (colocalizes) with

gene/protein

ENO2

in AD
Drugbank entries Show/Hide entries for ENO2
Comment Concanavalin-A (Con-A) binds to N-linked glycoproteins, but hydrophobic sites on non-glycoproteins are also known to bind Con-A.
Formal Description
Interaction-ID: 35099

drug/chemical compound

Concanavalin-A

interacts (colocalizes) with

drug/chemical compound

N-linked glycoprotein

Comment Concanavalin-A (Con-A) binds to N-linked glycoproteins, but hydrophobic sites on non-glycoproteins are also known to bind Con-A.
Formal Description
Interaction-ID: 35100

drug/chemical compound

Concanavalin-A

interacts (colocalizes) with

drug/chemical compound

Non-glycoprotein (hydrophobic sites)