General Information:

Id: 3,659 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Reference: Prentki M and Madiraju SR(2012) Glycerolipid/free fatty acid cycle and islet beta-cell function in health, obesity and diabetes Mol. Cell. Endocrinol. 353: 88-100 [PMID: 22108437]

Interaction Information:

Comment Hydrolysis of PA by lipins produces sn1,2-DAG, which is known to bind with the C1-domains of many proteins involved in the insulin secretory pathway, including the priming exocytotic effector Munc13-1, protein kinase C enzymes, and protein kinase D. Munc13-1 is a vesicle priming effector activated by DAG and the evidence indicates similar function in the beta-cell. Lowered Munc13-1 expression results in reduced circulating insulin levels, glucose intolerance and curtailed GSIS in isolated mouse islets. Thus, it has been proposed that DAG-mediated activation of Munc13-1 provides a link between glucose-induced lipolysis in the beta-cell and the amplification arm of fuel induced insulin secretion.
Formal Description
Interaction-ID: 35003