General Information:

Id: 3,659 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Reference: Prentki M and Madiraju SR(2012) Glycerolipid/free fatty acid cycle and islet beta-cell function in health, obesity and diabetes Mol. Cell. Endocrinol. 353: 88-100 [PMID: 22108437]

Interaction Information:

Comment Besides HSL, DAG can also be hydrolyzed by the plasma membrane associated sn1-DAG lipases alpha and beta, which are different gene products. Inhibition of islet DAG hydrolysis by the DAGL inhibitor RHC80267 decreases GSIS.
Formal Description
Interaction-ID: 34984