General Information:

Id: 3,659 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Reference: Prentki M and Madiraju SR(2012) Glycerolipid/free fatty acid cycle and islet beta-cell function in health, obesity and diabetes Mol. Cell. Endocrinol. 353: 88-100 [PMID: 22108437]

Interaction Information:

Comment The final step of lipogenesis is the synthesis of TG from DAG, catalyzed by DGAT-1 and DGAT-2. Both of these enzymes are present on the ER and also on lipid droplets. DGAT-1-KO mice were shown to have increased insulin sensitivity and enhanced glucose tolerance and are resistant to diet-induced obesity. Overexpression of DGAT-1 in rat islet cells has been shown to enhance TG synthesis and to cause decreased GSIS, supporting the view that DAG or its derivatives is implicated in insulin secretion.
Formal Description
Interaction-ID: 34929