General Information:

Id: 3,659 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Reference: Prentki M and Madiraju SR(2012) Glycerolipid/free fatty acid cycle and islet beta-cell function in health, obesity and diabetes Mol. Cell. Endocrinol. 353: 88-100 [PMID: 22108437]

Interaction Information:

Comment Enhancing the expression of GPAT-1 in the beta-cell does not alter GSIS, suggesting no direct relation between this isoenzyme, LPA levels and insulin secretion. This is consistent with previous work that showed no effect of exogenous LPA on insulin secretion in isolated rat islets, although lysophatidylinositol was effective.
Formal Description
Interaction-ID: 34913