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Field	Query

Alzheimer disease
Amyotrophic lateral sclerosis
Autism
Bipolar disorder
COXPD
Cancer
Cardiovascular diseases
Diabetes mellitus, type II
Epilepsy
Farber lipogranulomatosis
Inflammatory bowel disease
Lung disease
Major depressive disorder
Multiple sclerosis
Muscular atrophy
Neutropenia, severe congenital
Other
Parkinson disease
Post-traumatic stress disorder
Postpartum depression
Rare disease
Schizophrenia

	Field	Term

General Information:

Id:	3,632 (click here to show other Interactions for entry)
Diseases:	Diabetes mellitus, type II - [OMIM] Fatty liver disease, nonalcoholic Insulin resistance Obesity - [OMIM]
Organism:	Mammalia
Publication type:	review
Reference:	Prawitt J et al.(2011) Bile acid metabolism and the pathogenesis of type 2 diabetes Curr Diab Rep 11: 160-166 [PMID: 21431855]

Interaction Information:

Comment	FXR controls adipocyte differentiation and function by promoting peroxisome proliferator-activated receptor-gamma activity and inhibiting the Wnt/beta-catenin pathway.
Formal Description Interaction-ID: 34487	gene/protein NR1H4 decreases_activity of process canonical Wnt signaling pathway
Drugbank entries	Show/Hide entries for NR1H4
Drugbank DB02545	Fexaramine not specified NR1H4
Drugbank DB06777	Chenodeoxycholic acid other NR1H4
Drugbank DB08220	(8alpha,10alpha,13alpha,17beta)-17-[(4-h ... not specified NR1H4
Drugbank DB02545	Fexaramine not specified NR1H4

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