General Information:

Id: 3,627
Diseases: Alzheimer disease - [OMIM]
Dementia
Mus musculus
N2 cell line
article
Reference: Qiao DL et al.(2012) Is vitamin D beneficial to Alzheimer disease? A surprising dilemma CNS Neurosci Ther 18: 601-603 [PMID: 22591405]

Interaction Information:

Comment Vitamin D3 (VD) significantly inhibits the release of TNF-alpha from N9 microglia cells after LPS stimulation in a dosage dependent manner.
Formal Description
Interaction-ID: 34333

drug/chemical compound

Vitamin D3

decreases_quantity of

gene/protein

TNF

from N9 microglia cells
Drugbank entries Show/Hide entries for TNF
Comment Vitamin D3 (VD) significantly increases the Abeta production and decreases sAPP-alpha release from Swe APP N2a cells.
Formal Description
Interaction-ID: 34336

drug/chemical compound

Vitamin D3

increases_quantity of

gene/protein

Amyloid beta peptide

from Swe APP N2a cells
Comment Patients with AD and other dementias had lower serum concentrations of vitamin D, and its concentrations were significantly elevated after year-round sun exposure (however, whether sun exposure had improved cognitive function was not mentioned).
Formal Description
Interaction-ID: 34337

affects_activity of

Patients with AD and other dementias had lower serum concentrations of vitamin D.
Comment Vitamin D was found to upregulate gamma-glutamyl transpeptidase and subsequently increase glutathione. Glutathione is an innate antioxidant which protects oligodendrocytes and the integrity of the nerve conduction pathway critical to mental processing.
Formal Description
Interaction-ID: 34338

drug/chemical compound

Vitamin D

increases_activity of

complex/PPI

Gamma-glutamyl transpeptidase

Comment Patients with AD and other dementias had lower serum concentrations of vitamin D, and its concentrations were significantly elevated after year-round sun exposure (however, whether sun exposure had improved cognitive function was not mentioned).
Formal Description
Interaction-ID: 34347

affects_activity of

disease

Dementia

Patients with AD and other dementias had lower serum concentrations of vitamin D.
Comment Patients with AD and other dementias had lower serum concentrations of vitamin D, and its concentrations were significantly elevated after year-round sun exposure (however, whether sun exposure had improved cognitive function was not mentioned).
Formal Description
Interaction-ID: 34348

environment

sun exposure

increases_quantity of

drug/chemical compound

Vitamin D

in patients with AD and other dementias had lower serum concentrations of vitamin D.
Comment Vitamin D was found to upregulate gamma-glutamyl transpeptidase and subsequently increase glutathione. Glutathione is an innate antioxidant which protects oligodendrocytes and the integrity of the nerve conduction pathway critical to mental processing.
Formal Description
Interaction-ID: 34349

drug/chemical compound

Vitamin D

increases_quantity of

drug/chemical compound

Glutathione

Drugbank entries Show/Hide entries for
Comment Vitamin D3 (VD) significantly increases the Abeta production and decreases sAPP-alpha release from Swe APP N2a cells. sAPP-alpha has neurotrophic properties, promoting neuronal survival in aging and neuropathological conditions. When neurotrophin synthesis is decreased, spatial memory and navigation will be compromised.
Formal Description
Interaction-ID: 34416

drug/chemical compound

Vitamin D3

decreases_quantity of

gene/protein

sAPP-alpha

from Swe APP N2a cells
Comment Vitamin D3 (VD) inhibits the release of proinflammatory cytokine, TNF-alpha, from microglia cells.
Formal Description
Interaction-ID: 34417

gene/protein

TNF

affects_activity of

gene/protein

Proinflammatory cytokine

Drugbank entries Show/Hide entries for TNF