General Information:

Id: 3,622 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Hyperthyroidism
Hypothyroidism
Insulin resistance
Mammalia
review
Reference: Brenta G(2011) Why can insulin resistance be a natural consequence of thyroid dysfunction J Thyroid Res 2011 [PMID: 21941681]

Interaction Information:

Comment PPAR gamma coactivator-1 alpha (PGC-1 alpha), a key transcriptional regulator of mitochondrial content and function, fatty acid oxidation, and gluconeogenesis, has been involved in the process whereby thyroid hormones regulate mitochondrial function. It has been shown that PGC-1 alpha gene expression is increased by T3, as much as 13-fold 6 hours after T3 treatment.
Formal Description
Interaction-ID: 34328

drug/chemical compound

Triiodothyronine

increases_expression of

gene/protein

PPARGC1A