General Information:

Id: 3,619
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Metabolic syndrome
Rattus norvegicus
male
article
Reference: Liaset B et al.(2011) Nutritional regulation of bile acid metabolism is associated with improved pathological characteristics of the metabolic syndrome J. Biol. Chem. 286 [PMID: 21680746]

Interaction Information:

Comment To demonstrate that endogenous bile acid (BA) metabolism could be altered by dietary protein source, rats were fed salmon protein hydrolysate (SPH)- or casein-based high fat diets for 46 days. Plasma BA concentrations were higher in SPH-treated rats, whereas total liver BA amounts were not statistically different.
Formal Description
Interaction-ID: 34222

environment

high-fat diet, salmon protein hydrolysate-based

increases_quantity of

drug/chemical compound

Bile salt

in blood plasma
Comment To demonstrate that endogenous bile acid (BA) metabolism could be altered by dietary protein source, rats were fed salmon protein hydrolysate (SPH)- or casein-based high fat diets for 46 days. Plasma BA concentrations were higher in SPH-treated rats, whereas total liver BA amounts were not statistically different.
Formal Description
Interaction-ID: 34223

environment

high-fat diet, salmon protein hydrolysate-based

NOT affects_quantity of

drug/chemical compound

Bile salt

in liver
Comment To demonstrate that endogenous bile acid (BA) metabolism could be altered by dietary protein source, rats were fed salmon protein hydrolysate (SPH)- or casein-based high fat diets for 46 days. Plasma BA concentrations were higher in SPH-treated rats, whereas total liver BA amounts were not statistically different.
Formal Description
Interaction-ID: 34224

environment

high-fat diet, casein-based

NOT affects_quantity of

drug/chemical compound

Bile salt

in blood plasma
Comment To demonstrate that endogenous bile acid (BA) metabolism could be altered by dietary protein source, rats were fed salmon protein hydrolysate (SPH)- or casein-based high fat diets for 46 days. Plasma BA concentrations were higher in SPH-treated rats, whereas total liver BA amounts were not statistically different.
Formal Description
Interaction-ID: 34225

environment

high-fat diet, casein-based

NOT affects_quantity of

drug/chemical compound

Bile salt

in liver
Comment The SPH-treated rats had significantly higher liver alpha-muricholic acid and tended to have lower cholic acid but higher beta-muricholic acid levels, relative to the casein-fed rats.
Formal Description
Interaction-ID: 34226

environment

high-fat diet, salmon protein hydrolysate-based

increases_quantity of

drug/chemical compound

alpha-Muricholate

in liver
Comment Body weight gain was reduced and at the end of the experiment mean body weight was 110 g lower in SPH-treated rats.
Formal Description
Interaction-ID: 34227

environment

high-fat diet, salmon protein hydrolysate-based

decreases_activity of

Comment Inclusion of cholestyramine successfully lowered plasma BA concentrations in the SPH-based diet, whereas liver BA levels remained unaltered.
Formal Description
Interaction-ID: 34228

drug/chemical compound

Colestyramine

decreases_quantity of

drug/chemical compound

Bile salt

in blood plasma; if supplemented to high-fat diet, salmon protein hydrolysate-based
Comment Inclusion of cholestyramine successfully lowered plasma BA concentrations in the SPH-based diet, whereas liver BA levels remained unaltered.
Formal Description
Interaction-ID: 34229

drug/chemical compound

Colestyramine

NOT affects_quantity of

drug/chemical compound

Bile salt

in liver; if supplemented to high-fat diet, salmon protein hydrolysate-based
Comment In agreement with the increased whole body heat production, fatty acid oxidation capacity was significantly higher in interscapular brown adipose tissue (iBAT) from SPH-fed rats compared with rats fed casein.
Formal Description
Interaction-ID: 34231

environment

high-fat diet, salmon protein hydrolysate-based

increases_activity of

in interscapular brown adipose tissue
Comment The higher heat production and fatty acid oxidation capacity in iBAT in SPH-fed rats was accompanied by induction of genes encoding Ucp1 and Dio2, although Pgc-1alpha expression was not significantly increased. The SPH-treated rats displayed higher expressions of Ucp1, Dio2, and Pgc-1alpha in white adipose tissues of subcutaneous origin (inguinal WAT) and of abdominal origin, eWAT and mesenteric WAT.
Formal Description
Interaction-ID: 34232

environment

high-fat diet, salmon protein hydrolysate-based

increases_expression of

gene/protein

UCP1

in interscapular brown adipose tissue, in white adipose tissue
Comment The higher heat production and fatty acid oxidation capacity in iBAT in SPH-fed rats was accompanied by induction of genes encoding Ucp1 and Dio2, although Pgc-1alpha expression was not significantly increased. The SPH-treated rats displayed higher expressions of Ucp1, Dio2, and Pgc-1alpha in white adipose tissues of subcutaneous origin (inguinal WAT) and of abdominal origin, eWAT and mesenteric WAT.
Formal Description
Interaction-ID: 34233

environment

high-fat diet, salmon protein hydrolysate-based

increases_expression of

gene/protein

DIO2

in interscapular brown adipose tissue, in white adipose tissue
Comment The higher heat production and fatty acid oxidation capacity in iBAT in SPH-fed rats was accompanied by induction of genes encoding Ucp1 and Dio2, although Pgc-1alpha expression was not significantly increased. The SPH-treated rats displayed higher expressions of Ucp1, Dio2, and Pgc-1alpha in white adipose tissues of subcutaneous origin (inguinal WAT) and of abdominal origin, eWAT and mesenteric WAT.
Formal Description
Interaction-ID: 34234

environment

high-fat diet, salmon protein hydrolysate-based

NOT increases_expression of

gene/protein

PPARGC1A

in interscapular brown adipose tissue
Comment The higher heat production and fatty acid oxidation capacity in iBAT in SPH-fed rats was accompanied by induction of genes encoding Ucp1 and Dio2, although Pgc-1alpha expression was not significantly increased. The SPH-treated rats displayed higher expressions of Ucp1, Dio2, and Pgc-1alpha in white adipose tissues of subcutaneous origin (inguinal WAT) and of abdominal origin, eWAT and mesenteric WAT.
Formal Description
Interaction-ID: 34235

environment

high-fat diet, salmon protein hydrolysate-based

increases_expression of

gene/protein

PPARGC1A

in white adipose tissue
Comment In contrast to previous reports from bile acid-fed mice, the authors observed a down-regulation of liver Ppar-alpha in the SPH-treated rats. Concomitantly, liver acyl-CoA oxidase 1 (Acox1) expression was reduced, whereas carnitine palmitoyltransferase 1a (Cpt-1a) mRNA level was unaltered.
Formal Description
Interaction-ID: 34237

environment

high-fat diet, salmon protein hydrolysate-based

decreases_expression of

gene/protein

PPARA

in liver
Drugbank entries Show/Hide entries for PPARA
Comment In contrast to previous reports from bile acid-fed mice, the authors observed a down-regulation of liver Ppar-alpha in the SPH-treated rats. Concomitantly, liver acyl-CoA oxidase 1 (Acox1) expression was reduced, whereas carnitine palmitoyltransferase 1a (Cpt-1a) mRNA level was unaltered.
Formal Description
Interaction-ID: 34238

environment

high-fat diet, salmon protein hydrolysate-based

decreases_expression of

gene/protein

ACOX1

in liver
Drugbank entries Show/Hide entries for ACOX1
Comment In contrast to previous reports from bile acid-fed mice, the authors observed a down-regulation of liver Ppar-alpha in the SPH-treated rats. Concomitantly, liver acyl-CoA oxidase 1 (Acox1) expression was reduced, whereas carnitine palmitoyltransferase 1a (Cpt-1a) mRNA level was unaltered.
Formal Description
Interaction-ID: 34239

environment

high-fat diet, salmon protein hydrolysate-based

NOT affects_expression of

gene/protein

CPT1A

in liver
Drugbank entries Show/Hide entries for CPT1A
Comment mRNA levels of both Ppar-beta/delta and its downstream target gene adipocyte differentiation-related protein (Adrp) were robustly increased in the livers of the SPH-treated rats. Activation of PPAR-beta/delta increases fat catabolism and energy uncoupling and thereby prevents lipid accumulation.
Formal Description
Interaction-ID: 34240

environment

high-fat diet, salmon protein hydrolysate-based

increases_expression of

gene/protein

PPARD

in liver
Drugbank entries Show/Hide entries for PPARD
Comment mRNA levels of both Ppar-beta/delta and its downstream target gene adipocyte differentiation-related protein (Adrp) were robustly increased in the livers of the SPH-treated rats. Activation of PPAR-beta/delta increases fat catabolism and energy uncoupling and thereby prevents lipid accumulation.
Formal Description
Interaction-ID: 34241

environment

high-fat diet, salmon protein hydrolysate-based

increases_expression of

gene/protein

PLIN2

in liver
Comment Despite unaltered Cpt-1a mRNA levels, the SPH-treated rats had significantly higher liver mitochondrial CPT-1 capacity. CPT-1 activity is regulated by malonyl-CoA. Of note, the expression of Acc2, which encodes the enzyme catalyzing the formation of the CPT-1-inhibitor malonyl-CoA, was down-regulated.
Formal Description
Interaction-ID: 34242

environment

high-fat diet, salmon protein hydrolysate-based

decreases_expression of

gene/protein

ACACB

in liver
Drugbank entries Show/Hide entries for ACACB
Comment In skeletal muscle, expressions of the peroxisome proliferator-activated receptor beta/delta target genes (Cpt-1b, Angptl4, Adrp, and Ucp3) were induced in SPH-treated rats.
Formal Description
Interaction-ID: 34243

environment

high-fat diet, salmon protein hydrolysate-based

increases_expression of

gene/protein

CPT1B

in muscle
Comment In skeletal muscle, expressions of the peroxisome proliferator-activated receptor beta/delta target genes (Cpt-1b, Angptl4, Adrp, and Ucp3) were induced in SPH-treated rats.
Formal Description
Interaction-ID: 34244

environment

high-fat diet, salmon protein hydrolysate-based

increases_expression of

gene/protein

ANGPTL4

in muscle
Comment In skeletal muscle, expressions of the peroxisome proliferator-activated receptor beta/delta target genes (Cpt-1b, Angptl4, Adrp, and Ucp3) were induced in SPH-treated rats.
Formal Description
Interaction-ID: 34245

environment

high-fat diet, salmon protein hydrolysate-based

increases_expression of

gene/protein

PLIN2

in muscle
Comment In skeletal muscle, expressions of the peroxisome proliferator-activated receptor beta/delta target genes (Cpt-1b, Angptl4, Adrp, and Ucp3) were induced in SPH-treated rats.
Formal Description
Interaction-ID: 34246

environment

high-fat diet, salmon protein hydrolysate-based

increases_expression of

gene/protein

UCP3

in muscle
Comment Plasma bile acid levels can be modulated by the dietary protein source in high fat-treated rats. Increased levels of plasma BAs were associated with a significant reduction in diet-induced obesity and resulted in increased whole body energy expenditure and dissipation of energy in the form of heat. Concomitantly, fed-state plasma glucose and TAG concentrations were reduced. Thus, a protein source-dependent increase in plasma BA levels appears to have the potential to attenuate pathological characteristics of the metabolic syndrome in the high fat-fed rats.
Formal Description
Interaction-ID: 34247

environment

high-fat diet, salmon protein hydrolysate-based

decreases_activity of

disease

Metabolic syndrome