General Information:

Id: 3,617 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
male
article
Reference: Watanabe M et al.(2012) Bile Acid Binding Resin Improves Metabolic Control through the Induction of Energy Expenditure PLoS ONE 7 [PMID: 22952571]

Interaction Information:

Comment Genes involved in gluconeogenesis, such as phosphoenolpyruvate carboxykinase (Pepck) and glucose-6-phophatase (G6Pase) were affected. Pepck gene expression was significantly induced, and G6Pase gene expression was also stimulated as a consequence of the significant rise in the Pgc-1a expression, which stimulates gluconeogenesis.
Formal Description
Interaction-ID: 34203

drug/chemical compound

Colestimide

increases_expression of

gene/protein

PPARGC1A

in liver
Comment In brown adipose tissue (BAT), the expression of Pgc-1alpha and D2 were both induced by colestimide and CA.
Formal Description
Interaction-ID: 34212

drug/chemical compound

Colestimide

increases_expression of

gene/protein

PPARGC1A

in brown adipose tissue
Comment In brown adipose tissue (BAT), the expression of Pgc-1alpha and D2 were both induced by colestimide and CA.
Formal Description
Interaction-ID: 34213

drug/chemical compound

Cholic acid

increases_expression of

gene/protein

PPARGC1A

in brown adipose tissue
Drugbank entries Show/Hide entries for Cholic acid
Comment Colestimide and CA treatment did not lead to significant differences in the expression of the genes involved in energy homeostasis in muscle.
Formal Description
Interaction-ID: 34216

drug/chemical compound

Colestimide

NOT affects_expression of

gene/protein

PPARGC1A

in muscle
Comment Colestimide and CA treatment did not lead to significant differences in the expression of the genes involved in energy homeostasis in muscle.
Formal Description
Interaction-ID: 34217

drug/chemical compound

Cholic acid

NOT affects_expression of

gene/protein

PPARGC1A

in muscle
Drugbank entries Show/Hide entries for Cholic acid