CIDeRGeneral Information:
| Id: | 3,617 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
| Mus musculus | |
| male | |
| article | |
| Reference: | Watanabe M et al.(2012) Bile Acid Binding Resin Improves Metabolic Control through the Induction of Energy Expenditure PLoS ONE 7 [PMID: 22952571] |
Interaction Information:
| Comment | Genes involved in gluconeogenesis, such as phosphoenolpyruvate carboxykinase (Pepck) and glucose-6-phophatase (G6Pase) were affected. Pepck gene expression was significantly induced, and G6Pase gene expression was also stimulated as a consequence of the significant rise in the Pgc-1a expression, which stimulates gluconeogenesis. |
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Formal Description Interaction-ID: 34203 |
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| Comment | In brown adipose tissue (BAT), the expression of Pgc-1alpha and D2 were both induced by colestimide and CA. |
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Formal Description Interaction-ID: 34212 |
drug/chemical compound increases_expression of gene/protein |
| Comment | In brown adipose tissue (BAT), the expression of Pgc-1alpha and D2 were both induced by colestimide and CA. |
|
Formal Description Interaction-ID: 34213 |
drug/chemical compound increases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for Cholic acid |
| Comment | Colestimide and CA treatment did not lead to significant differences in the expression of the genes involved in energy homeostasis in muscle. |
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Formal Description Interaction-ID: 34216 |
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| Comment | Colestimide and CA treatment did not lead to significant differences in the expression of the genes involved in energy homeostasis in muscle. |
|
Formal Description Interaction-ID: 34217 |
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| Drugbank entries | Show/Hide entries for Cholic acid |