General Information:

Id: 3,617 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
male
article
Reference: Watanabe M et al.(2012) Bile Acid Binding Resin Improves Metabolic Control through the Induction of Energy Expenditure PLoS ONE 7 [PMID: 22952571]

Interaction Information:

Comment Genes involved in gluconeogenesis, such as phosphoenolpyruvate carboxykinase (Pepck) and glucose-6-phophatase (G6Pase) were affected. Pepck gene expression was significantly induced, and G6Pase gene expression was also stimulated as a consequence of the significant rise in the Pgc-1a expression, which stimulates gluconeogenesis.
Formal Description
Interaction-ID: 34203

drug/chemical compound

Colestimide

increases_expression of

gene/protein

PPARGC1A

in liver