General Information:

Id: 3,615 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mus musculus
article
Reference: Watanabe M et al.(2006) Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation Nature 439: 484-489 [PMID: 16400329]

Interaction Information:

Comment The expression of key genes in energy expenditure such as the peroxisome-proliferator-activated receptor gamma coactivator (PGC)-1alpha, PGC-1beta, uncoupling protein (UCP)-1, UCP-3, straight-chain acyl-CoA oxidase 1 (ACO), muscle-type carnitine palmitoyltransferase I (mCPT-I) and D2 was significantly increased in BAT after BA feeding. Similar changes were not observed in liver or muscle. FXR-alpha and SHP expression was not detected in BAT under any of the conditions, whereas the induction of SHP by BAs in liver was confirmed.
Formal Description
Interaction-ID: 34135

drug/chemical compound

Cholic acid

increases_expression of

gene/protein

PPARGC1A

in brown adipose tissue
Drugbank entries Show/Hide entries for Cholic acid