General Information:

Id: 3,576 (click here to show other Interactions for entry)
Diseases: Cholestasis, progressive familial intrahepatic 2 - [OMIM]
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Reference: Li T and Chiang JY(2012) Bile Acid signaling in liver metabolism and diseases J Lipids 2012 [PMID: 21991404]

Interaction Information:

Comment Initial evidence that bile acids may regulate glucose metabolism came from studies showing that FXR (NR1H4) agonist induced phosphoenolpyruvate carboxykinase (PEPCK) mRNA expression and glucose output in human and rat hepatocytes.
Formal Description
Interaction-ID: 33492

drug/chemical compound

Bile salt

affects_activity of

via NR1H4