General Information:

Id: 3,571 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
male
article
Reference: Cariou B et al.(2006) The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice J. Biol. Chem. 281 [PMID: 16446356]

Interaction Information:

Comment FFA and fatty acid metabolites are known to act as endogenous ligands of both PPARalpha and -beta/delta. In accordance with the increased circulating FFA concentrations in FXR-/- mice, both PPARalpha and PPARbeta/delta mRNA levels were increased in skeletal muscle of FXR-/- mice. Moreover, a broad program of known PPARalpha-beta/delta target genes involved in cellular FFA uptake, triglyceride synthesis, and mitochondrial and peroxisomal beta-oxidation was stimulated in muscle of FXR-/- mice. These results suggest that FXR influences energy substrate partitioning (i.e. FFA versus glucose) in skeletal muscle.
Formal Description
Interaction-ID: 33418

gene/protein

NR1H4

affects_expression of

gene/protein

PPARA

in skeletal muscle
Drugbank entries Show/Hide entries for NR1H4 or PPARA