General Information:

Id: 357
Diseases: Parkinson disease
Rattus norvegicus
BTO:0000138 midbrain
article
Reference: McCoy MK et al.(2006) Blocking soluble tumor necrosis factor signaling with dominant-negative tumor necrosis factor inhibitor attenuates loss of dopaminergic neurons in models of Parkinsons disease. J. Neurosci. 26: 9365-9375 [PMID: 16971520]

Interaction Information:

Comment TNF levels have been reported to increase in striatum and substantia nigra of 6-OHDA-injected rats.
Formal Description
Interaction-ID: 1417

drug/chemical compound

6-OHDA

increases_quantity of

gene/protein

TNF

in striatum and substantia nigra
Drugbank entries Show/Hide entries for TNF
Comment Blocking soluble TNF signaling with experimental TNF inhibitor called XENP345 in vivo, provides neuroprotection to dopamine neurons from 6-OHDA-induced death.
Formal Description
Interaction-ID: 1419

drug/chemical compound

XENP345

decreases_activity of

gene/protein

TNF

Drugbank entries Show/Hide entries for TNF
Comment Blocking soluble TNF signaling with experimental TNF inhibitor called XENP345 in vivo, provides neuroprotection to dopamine neurons from 6-OHDA-induced death.
Formal Description
Interaction-ID: 1420

drug/chemical compound

XENP345

decreases_activity of

process

neuron death

Comment Blocking soluble TNF signaling with experimental TNF inhibitor called XENP345 in vivo, provides neuroprotection to dopamine neurons from 6-OHDA-induced death.
Formal Description
Interaction-ID: 1421

gene/protein

TNF

increases_activity of

process

neuron death

Drugbank entries Show/Hide entries for TNF
Comment Blocking soluble TNF signaling with experimental TNF inhibitor called XENP345 in vivo, provides neuroprotection to dopamine neurons from 6-OHDA-induced death.
Formal Description
Interaction-ID: 1422

increases_activity of

process

neuron death