General Information:

Id: 3,567 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Gallbladder disease 1 - [OMIM]
Insulin resistance
Mus musculus
male
LIRKO mouse: liver-specific disruption of the insulin receptor
article
Reference: Biddinger SB et al.(2008) Hepatic insulin resistance directly promotes formation of cholesterol gallstones Nat. Med. 14: 778-782 [PMID: 18587407]

Interaction Information:

Comment Gallbladder volume was increased threefold in LIRKO mice, consistent with impaired motility and increased biliary cholesterol content. Because fractional cholesterol absorption from the gut was similar in Lox and LIRKO mice, the absolute amount of cholesterol absorbed from the gut in LIRKO mice should be increased because of their high levels of biliary cholesterol secretion. This was associated with a twofold increase in hepatic cholesterol and decreased expression of sterol regulatory element-binding protein-2 and its targets.
Formal Description
Interaction-ID: 33332

organism model

LIRKO mouse

increases_quantity of

drug/chemical compound

Cholesterol

in liver
Drugbank entries Show/Hide entries for