General Information:

Id: 355 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mus musculus
BTO:0000142 brain, cultured neurons
Reference: Yang DS et al.(2002) Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins J. Biol. Chem. 277 [PMID: 12032140]

Interaction Information:

Comment Immunoprecipitation revealed that presenilin-1 interacts preferentially with mature nicastrin, suggesting that correct trafficking and co-localization of the presenilin complex components are essential for activity. There are two potential interpretations for the preferential interaction of PSEN1 with the mature, glycosylated form of nicastrin: One possibility is that the interaction is directly due to the glycosylation state of the mature form, which alters nicastrin structure and facilitates binding to PSEN1. However, it is more likely that the maturation process is simply a marker of trafficking and is, therefore, an indicator of movement of nicastrin past the ER and to compartments where it can assemble with PSEN1 to produce a functional complex.
Formal Description
Interaction-ID: 1445



interacts (colocalizes) with