General Information:

Id: 3,552 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mus musculus
FeCgamma25 transgenic mouse; Fe27 transgenic mouse
article
Reference: Ghosal K et al.(2010) APP intracellular domain impairs adult neurogenesis in transgenic mice by inducing neuroinflammation PLoS ONE 5 [PMID: 20689579]

Interaction Information:

Comment Non-steroidal anti-inflammatory drug (NSAID; ibuprofen) treatment rescued impaired adult hippocampal neurogenesis in FeCgamma25 mice. Ibuprofen treatment for 2 months (right) can decrease neuroinflammation and rescue decreased adult hippocampal cell proliferation.
Formal Description
Interaction-ID: 33002

drug/chemical compound

Ibuprofen

decreases_activity of

phenotype

neuroinflammation

Drugbank entries Show/Hide entries for Ibuprofen