General Information:

Id: 3,552
Diseases: Alzheimer disease - [OMIM]
Mus musculus
FeCgamma25 transgenic mouse; Fe27 transgenic mouse
article
Reference: Ghosal K et al.(2010) APP intracellular domain impairs adult neurogenesis in transgenic mice by inducing neuroinflammation PLoS ONE 5 [PMID: 20689579]

Interaction Information:

Comment AICD can exacerbate memory defects in AD by impairing adult neurogenesis.
Formal Description
Interaction-ID: 32996

decreases_activity of

process

memory

in AD by impairing adult neurogenesis
Comment AICD can exacerbate memory defects in AD by impairing adult neurogenesis.
Formal Description
Interaction-ID: 32997

decreases_activity of

process

neurogenesis

in AD
Comment Non-steroidal anti-inflammatory drug (NSAID; ibuprofen) treatment rescued impaired adult hippocampal neurogenesis in FeCgamma25 mice. Ibuprofen treatment for 2 months (right) can decrease neuroinflammation and rescue decreased adult hippocampal cell proliferation.
Formal Description
Interaction-ID: 32999

drug/chemical compound

Ibuprofen

increases_activity of

process

neurogenesis

Drugbank entries Show/Hide entries for Ibuprofen
Comment Both drugs, ibuprofen and naproxen, protected against AICD-induced defects in adult neurogenesis.
Formal Description
Interaction-ID: 33000

drug/chemical compound

Naproxen

affects_activity of

process

neurogenesis

(protects against AICD-induced defects in adult neurogenesis)
Drugbank entries Show/Hide entries for Naproxen
Comment Non-steroidal anti-inflammatory drug (NSAID; ibuprofen) treatment rescued impaired adult hippocampal neurogenesis in FeCgamma25 mice. Ibuprofen treatment for 2 months (right) can decrease neuroinflammation and rescue decreased adult hippocampal cell proliferation.
Formal Description
Interaction-ID: 33002

drug/chemical compound

Ibuprofen

decreases_activity of

phenotype

neuroinflammation

Drugbank entries Show/Hide entries for Ibuprofen
Comment Non-steroidal anti-inflammatory drug (NSAID; ibuprofen) treatment rescued impaired adult hippocampal neurogenesis in FeCgamma25 mice. Ibuprofen treatment for 2 months (right) can decrease neuroinflammation and rescue decreased adult hippocampal cell proliferation.
Formal Description
Interaction-ID: 33003

drug/chemical compound

Ibuprofen

increases_activity of

Ibuprofen can rescue decreased adult hippocampal cell proliferation.
Drugbank entries Show/Hide entries for Ibuprofen