General Information:

Id: 3,540
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
article
Reference: Weggen S et al.(2003) Abeta42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain J. Biol. Chem. 278 [PMID: 12777371]

Interaction Information:

Comment Neither sulindac sulfide nor ibuprofen reduces AICD production.
Formal Description
Interaction-ID: 32937

drug/chemical compound

Ibuprofen

NOT decreases_quantity of

Drugbank entries Show/Hide entries for Ibuprofen
Comment Neither sulindac sulfide nor ibuprofen reduces AICD production.
Formal Description
Interaction-ID: 32990

drug/chemical compound

Sulindac sulfide

NOT decreases_quantity of

Comment Neither sulindac sulfide nor ibuprofen reduces AICD production as compared with dimethyl sulfoxide-treated (DMSO) control cells.
Formal Description
Interaction-ID: 32991

drug/chemical compound

Dimethyl sulfoxide

decreases_quantity of

Comment Abeta42-lowering NSAIDs (Non-steroid antiinflammatory drugs) do not impair AICD or ErbB4 C-terminal fragment generation.
Formal Description
Interaction-ID: 32992

drug/chemical compound

NSAID

decreases_quantity of

Comment Abeta42-lowering NSAIDs (Non-steroid antiinflammatory drugs)do not impair AICD or ErbB4 C-terminal fragment generation.
Formal Description
Interaction-ID: 32993

drug/chemical compound

NSAID

NOT decreases_quantity of

Comment Abeta42-lowering NSAIDs (Non-steroid antiinflammatory drugs)do not impair AICD or ErbB4 C-terminal fragment generation.
Formal Description
Interaction-ID: 32994

drug/chemical compound

NSAID

NOT decreases_quantity of