General Information:

Id: 3,503 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
male
PPARalpha-/- mouse
article
Reference: Makowski L et al.(2009) Metabolic profiling of PPARalpha-/- mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation FASEB J. 23: 586-604 [PMID: 18945875]

Interaction Information:

Comment The study examined hepatic transamination capacity by measuring mRNA levels of the cytosolic and mitochondrial isoforms of glutamateoxaloacetate transaminase (GOT1 and GOT2, respectively) and tyrosine aminotransferase (TAT). In wildtype mice, expression of these genes was unaffected by fasting, implying a relatively low drive for amino acid catabolism. Conversely, in PPARalpha -/- mice, overnight fasting increased hepatic mRNA levels of GOT1 and TAT 3.2- and 4.4-fold, respectively, whereas expression of the mitochondrial GOT2 mRNA was unchanged. These results fit with the known roles of the GOT1 and TAT reactions in providing amino acid-derived carbon backbones for gluconeogenesis and ketogenesis, respectively, and might explain the marked fasting-induced depletion of alpha-ketoglutarate and tyrosine in PPARalpha -/- mice.
Formal Description
Interaction-ID: 32625

gene/protein

PPARA

affects_expression of

gene/protein

TAT

in liver
Drugbank entries Show/Hide entries for PPARA or TAT